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Description Role of AIM2 in atherosclerosis. dsDNA released from necrotic cells during advanced atherosclerosis activates the AIM2 inflammasome in macrophages and releases inflammasome effector cytokines,...
Article Title: Role of AIM2 inflammasome in inflammatory diseases, cancer and infection
Publication Title: European Journal of Immunology -
Description Negative regulators of MAVS. Additional negative regulators prevent or diminish the activity of MAVS, which blocks downstream formation of the signaling synapse and transcription factors. A20 may...
Article Title: Negative regulators of the RIG‐I‐like receptor signaling pathway
Publication Title: European Journal of Immunology -
Description Native and denatured class I HLA expression on cells used for antibody depletion assays. (A) Gating strategy used for FACS analysis of native (W6/32 mAb, continuous line) and denatured (HC‐10 mAb,...
Article Title: Deciphering allogeneic antibody response against native and denatured HLA epitopes in organ transplantation
Publication Title: European Journal of Immunology -
Description Glycolytic ATP production and active cytoskeletal rearrangements are required for NET formation. ROS‐induced actin and tubulin glutathionylation controls cell cytoskeletal dynamics and NET...
Article Title: Untangling “NETosis” from NETs
Publication Title: European Journal of Immunology -
Description Primers used for genotyping
Article Title: IFN regulatory factor (IRF) 3/7‐dependent and ‐independent gene induction by mammalian DNA that escapes degradation
Publication Title: European Journal of Immunology -
Description CD107a/b mobilization and production of cytokines after stimulation with TV9p6 or TV9 loaded onto C1R‐A2wt cells in three sets of parallel CTL culturesa)
Article Title: Generation of robust CD8+ T‐cell responses against subdominant epitopes in conserved regions of HIV‐1 by repertoire mining with mimotopes
Publication Title: European Journal of Immunology -
Description Impact of hydrogen bonds between the two helical regions of α and β chains near the P1 pocket of DQ8 molecule. (A) Top view of the two helical regions of DQ8 α and β chains near the P1 pocket of...
Article Title: Type 1 diabetes associated HLA‐DQ2 and DQ8 molecules are relatively resistant to HLA‐DM mediated release of invariant chain‐derived CLIP peptides
Publication Title: European Journal of Immunology -
Description B‐cell intrinsic regulation of IgG1 and IgE CSR in the humoral type 2 immune response. Signaling via the IL‐4 receptor (IL‐4 R) leads to activation of the transcription factor STAT6 which...
Article Title: Regulation of the humoral type 2 immune response against allergens and helminths
Publication Title: European Journal of Immunology -
Description CD163− Infl mo‐like cells and shifted CD163+MΦ express distinct molecular profile. (A) CD14+CD64+CD163− (Gγ23, day 6), CD14+CD64+CD163− (TGF‐β + IL10, day 12), and CD14+CD64+CD163+ (TGF‐β + IL10,...
Article Title: A two‐step human culture system replicates intestinal monocyte maturation cascade: Conversion of tissue‐like inflammatory monocytes into macrophages
Publication Title: European Journal of Immunology -
Description Human splenic polymorphonuclear myeloid‐derived suppressor cells (PMN‐MDSC) are strategically located immune regulatory cells in cancerEce Tavukcuoglu et al. - European Journal of ImmunologyEur. J....
Article Title: Human splenic polymorphonuclear myeloid‐derived suppressor cells (PMN‐MDSC) are strategically located immune regulatory cells in cancer
Publication Title: European Journal of Immunology -
Description Effect of exogenous IL‐10 on LPS‐induced expression of costimulatory molecules, MHC II, and cytokines in IL‐10−/− and WT DCs. DCs were generated from bone marrow of WT and IL‐10−/– mice. On day 8...
Article Title: IL‐10 deficiency blocks the ability of LPS to regulate expression of tolerance‐related molecules on dendritic cells
Publication Title: European Journal of Immunology -
Description Treatment of RA reduces cytokine levels in serum but does not regulate liver injury during α‐GalCer‐induced hepatitis. (A) ATRA (35 mg/kg) or vehicle (DMSO) was administered to C57Bl/6 mice i.p.,...
Article Title: Retinoic acid alleviates Con A‐induced hepatitis and differentially regulates effector production in NKT cells
Publication Title: European Journal of Immunology -
Description Both natural infection with Pneumocystis and the exposure of the lungs to nonreplicative VLPs provide protection against morbidity, and enhance the clearance of an unrelated pathogen. WT (BALB/c)...
Article Title: CD11c+ cells primed with unrelated antigens facilitate an accelerated immune response to influenza virus in mice
Publication Title: European Journal of Immunology -
Description Foxn1 and eGFP gradually decrease with age. Foxn1 and eGFP expression in TEC subsets from Foxn1eGFP/+ mice were analyzed at both the protein and mRNA levels by flow cytometry and qPCR,...
Article Title: A novel Foxn1eGFP/+ mouse model identifies Bmp4‐induced maintenance of Foxn1 expression and thymic epithelial progenitor populations
Publication Title: European Journal of Immunology -
Description FTY720 but not FTY720‐P inhibits the IL‐33/IL‐12 induced IFN‐γ formation of primary murine splenocytes and CD8+ T cells. (A–F) Primary murine splenocytes and CD8+ T cells were stimulated with...
Article Title: Fingolimod targeting protein phosphatase 2A differently affects IL‐33 induced IL‐2 and IFN‐γ production in CD8+ lymphocytes
Publication Title: European Journal of Immunology -
Description Decreased numbers of γδ T cells in secondary lymphoid organs of CCR7−/− mice. (A–C) Spleen and pLNs of 6‐week‐old WT TcrdH2BeGFP (WT), Ccr7−/− × TcrdH2BeGFP (CCR7−/−), or Ccr9−/− × TcrdH2BeGFP...
Article Title: CCR7‐mediated migration in the thymus controls γδ T‐cell development
Publication Title: European Journal of Immunology -
Description Upregulation of hCAT‐1 mRNA is comparably induced upon activation of both naïve and memory CD4+ human T cells. (A–C) Human CD4+ naïve (CD45RA+, CD45RO−) T cells and (D–F) CD4+ memory (CD45RA−,...
Article Title: Induced arginine transport via cationic amino acid transporter‐1 is necessary for human T‐cell proliferation
Publication Title: European Journal of Immunology -
Description Comparison of the T‐cell priming in IL‐10−/− and C57BL/6 mice after Docile or Clone 13 infection. One day prior to infection with 106 pfu of either LCMV Docile or LCMV Clone 13, groups of three...
Article Title: Reversal of chronic to resolved infection by IL‐10 blockade is LCMV strain dependent
Publication Title: European Journal of Immunology -
Description IL‐9R expression in tumor‐infiltrating lymphocytes (TIL) from melanoma patients. (A, B) DP and SP CD8 T cells were isolated from tumor‐infiltrating lymphocytes (TILs) of melanoma patients and...
Article Title: IL‐9 promotes the survival and function of human melanoma‐infiltrating CD4+CD8+ double‐positive T cells
Publication Title: European Journal of Immunology -
Description Ex vivo production of IL‐13 by strictured Crohn's disease (CD) tissue. Levels of IL‐13 and IL‐1β, expressed as pg/mL, and collagen, expressed as μg/mL, in the supernatants of muscle layer explants...
Article Title: Absence of a role for interleukin‐13 in inflammatory bowel disease
Publication Title: European Journal of Immunology -
Description Comparison of phenotype analyses of tumor‐infiltrating leucocytes (TILs) of control tumor‐bearing mice and treated tumor‐bearing mice. (A–H) Mice inoculated with WEHI‐164 or C51 tumor cells were...
Article Title: The therapeutic T‐cell response induced by tumor delivery of TNF and melphalan is dependent on early triggering of natural killer and dendritic cells
Publication Title: European Journal of Immunology -
Description Development of microbiota‐specific T cells in the intestines and spleens. 2 × 106 CBir1 TCR Tg T cells were transferred into RAG−/− mice. Four weeks later, mice were sacrificed. (A) Intestinal...
Article Title: Commensal A4 bacteria inhibit intestinal Th2‐cell responses through induction of dendritic cell TGF‐β production
Publication Title: European Journal of Immunology -
Description Long‐term CXCR4 blockade with AMD3100 after short‐term depletion of ASCs (bortezomib plus AMD3100 for two weeks) until the age of 8 months delays the proteinuria development and improves survival...
Article Title: CXCR4–CXCL12 interaction is important for plasma cell homing and survival in NZB/W mice
Publication Title: European Journal of Immunology -
Description IL‐10‐producing Tcells infiltrate in the lung. (A) H& E staining of lung tissues at 7 and 58 weeks of age are shown at 10× magnification; enlarged views (boxed areas) from 58‐week‐old mice are...
Article Title: Enhanced GITR/GITRL interactions augment IL‐27 expression and induce IL‐10‐producing Tr‐1 like cells
Publication Title: European Journal of Immunology -
Description Complex I‐derived ROS is bactericidal and drives cytokine production. (A) ROS is directly bactericidal. LPS signaling induces tumor necrosis factor receptor‐associated factor 6 (TRAF6) recruitment...
Article Title: Reprogramming mitochondrial metabolism in macrophages as an anti‐inflammatory signal
Publication Title: European Journal of Immunology -
Description Schematic representation of IL‐17 immunity, and cooperation between cells recognizing C. albicans (phagocytes and epithelial cells) and cells producing IL‐17 cytokines (T and innate (NK)...
Article Title: Immunity to infection in IL‐17‐deficient mice and humans
Publication Title: European Journal of Immunology -
Description Reduction of HuR using siRNA or shRNA results in decreased type I IFN response. (A) HelaS3 cells were treated with siRNA, total RNA was isolated, and qRT‐PCR was performed using primers specific...
Article Title: The RNA‐binding protein HuR/ELAVL1 regulates IFN‐β mRNA abundance and the type I IFN response
Publication Title: European Journal of Immunology -
Description The prevalence of myeloid cell subsets within the BM is strain specific. (A, B) Flow cytometric analysis of (A) C57BL/6 and (B) BALB/c BM cells was performed. The single‐cell suspensions from...
Article Title: Myeloid‐derived suppressor cell functionality and interaction with Leishmania major parasites differ in C57BL/6 and BALB/c mice
Publication Title: European Journal of Immunology -
Description CD3‐NK1.1+ cells traffic to the MLN and are activated at sites of infection. C57BL/6 mice were infected orally with 108 C. rodentium and euthanized at various days post infection. (A) General...
Article Title: CD3−NK1.1+ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen
Publication Title: European Journal of Immunology -
Description Signaling induced by low‐affinity antigens is relatively more dependent on LFA‐1 in comparison to high‐affinity antigens. (A) DDAO+ OT‐I T cells were activated by mixing with WT splenocytes...
Article Title: Opposing effects of actin signaling and LFA‐1 on establishing the affinity threshold for inducing effector T‐cell responses in mice
Publication Title: European Journal of Immunology