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Description In vivo antitumor activities of aPD-1/aPD-L1 mAb. C3H mice were injected subcutaneously with MM48 cells on day 0. Tumor-bearing mice were intraperitoneally treated with Abs at the indicated doses...
Article Title: Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Strategy for identifying tumor-infiltrating immune-related lncRNA signature (TILSig) in this study. Top 5% expressed long non-coding RNAs (lncRNAs) were obtained as candidate immune-related lncRNAs...
Article Title: Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung cancer
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Individual patient characteristics and responses
Article Title: Regulatory T-cell depletion in the setting of autologous stem cell transplantation for multiple myeloma: pilot study
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Evaluation of a human iaIL-12 construct in vitro. (A) Schematic representation of retroviral inserts for expression of human IL-12 constructs. (B,C) Human T cells were transduced to express in the...
Article Title: Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models
Publication Title: Journal for ImmunoTherapy of Cancer -
Description EVTRD from an autologous stem cell graft using anti-CD25 microbeads and the CliniMACS device. The predepletion lymphocyte population is identified in (A), and relative CD4+CD25+/CD4+ T cells are...
Article Title: Regulatory T-cell depletion in the setting of autologous stem cell transplantation for multiple myeloma: pilot study
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Histotripsy inhibits the development of distant pulmonary metastases. C57BL/6 mice were inoculated with flank and intravenous inoculations of B16GP33 melanoma on days 0 and 3, respectively. Sham...
Article Title: Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy
Publication Title: Journal for ImmunoTherapy of Cancer -
Description (A) Progression-free (PFS) and (B) overall survival (OS) in all patients and by breast cancer subtype. ER+, endocrine-refractory-positive; HR+, hormonereceptor-positive endocrine-refractory; TNBC,...
Article Title: Phase II study of pembrolizumab and capecitabine for triple negative and hormone receptor-positive, HER2−negative endocrine-refractory metastatic breast cancer
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Non-hematological adverse events
Article Title: Regulatory T-cell depletion in the setting of autologous stem cell transplantation for multiple myeloma: pilot study
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Multivariate analyses of prognostic factors correlated with PFS and OS
Article Title: HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description PD-1 expression in TRBV3-1 clonotypes. (A) The fraction (left) and the median of fluorescence (right) of PD-1 expressing T cells were measured on the seven TRBV3-1 clonotypes. PD-1 expression was...
Article Title: Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Response to immune checkpoint inhibitors (ICIs) for patients in the discontinuation and retreatment cohorts. (A) Best response achieved prior to immune-related adverse event (irAE) and the best...
Article Title: Safety and efficacy of restarting immune checkpoint inhibitors after clinically significant immune-related adverse events in metastatic renal cell carcinoma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description The effect of excess unlabeled mAbs on biodistribution in tumor-bearing mice. (A) The kinetic profiles of mAb concentrations in the blood associated with I-125 radioactivity following injection at...
Article Title: Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Treatment-related select adverse events for chemotherapy
Article Title: Propensity score–weighted analysis of chemotherapy after PD-1 inhibitors versus chemotherapy alone in patients with non–small cell lung cancer (WJOG10217L)
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Unadjusted patient characteristics for the chemotherapy after PD-1 inhibitor treatment (CAP) and control cohorts
Article Title: Propensity score–weighted analysis of chemotherapy after PD-1 inhibitors versus chemotherapy alone in patients with non–small cell lung cancer (WJOG10217L)
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Cytokine modulation in ex vivo tumor cultures during oncolytic adenovirus therapy. Supernatants from patient ex vivo tumor cultures were harvested on day 3 and day 6 or 7 for analysis of...
Article Title: Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity
Publication Title: Journal for ImmunoTherapy of Cancer -
Description The association of HHLA2 expression level with clinicopathological characteristics in the training cohort and validation cohort
Article Title: HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Biodistribution of aPD-1 and aPD-L1 mAbs at high dose. (A) aPD-1 and aPD-L1 mAb concentrations in the blood associated with I-125 radioactivity were measured at 3, 48, 120, and 216 hours following...
Article Title: Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Characteristics of patients with ovarian cancer
Article Title: Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity
Publication Title: Journal for ImmunoTherapy of Cancer -
Description EVTRD from ASC grafts is highly efficient. Frequencies of CD4+CD25+ Treg cells in each ASC graft are shown prior to and following the EVTRD procedure (p=0.0049). ASC, autologous stem cell; EVTRD,...
Article Title: Regulatory T-cell depletion in the setting of autologous stem cell transplantation for multiple myeloma: pilot study
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Kaplan-Meier survival curves for PFS and OS of patients with ccRCC according to HHLA2 and PD-L1 expression. (A) PFS and OS according to HHLA2 expression status in the training cohort and validation...
Article Title: HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Antitumor efficiency of the adoptive transfer of WT4 and KO6 T cell clones. (A) Growth curves of engrafted M113 (up) and M113PD-L1+ melanoma cells (down), in NSG mice receiving intravenous...
Article Title: Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Inverse probability weighting (IPW)–adjusted Kaplan-Meier analysis of overall survival (OS) for the chemotherapy after PD-1 inhibitor treatment (CAP) cohort versus the control cohort. Comparisons...
Article Title: Propensity score–weighted analysis of chemotherapy after PD-1 inhibitors versus chemotherapy alone in patients with non–small cell lung cancer (WJOG10217L)
Publication Title: Journal for ImmunoTherapy of Cancer -
Description PD-1 expression on PDCD1-edited T cell clones. PD-1 expression was analyzed by flow cytometry after activation of T cell clones with anti-CD3 antibody (400 ng/mL, 12 hours). T cell clones were...
Article Title: Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Evaluation of an inducible anchored murine IL-12 construct in vitro. (A) Schematic representation of retroviral vector inserts for murine IL-12 constructs. (B) Human T cells were transduced with...
Article Title: Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Effect of anti-PD1 therapy to murine pancreatic cancer (PC) tumor. Mice were ectopic inoculated with BxPC-3 and Panc-1 PC cells, control immunoglobulin G (No treatment) or anti-PD1 blocking...
Article Title: Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Representative micrographs of CD8 (A) and CD4 (B) expression and the corresponding negative controls within the tumor. Scatter plot depicted the correlation between HHLA2 and PD-L1 expression and...
Article Title: HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Graphical abstract.
Article Title: Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer
Publication Title: Journal for ImmunoTherapy of Cancer -
Description CONSORT diagram. CAP, chemotherapy after PD-1 inhibitor treatment; IPW, inverse probability weighting; OS, overall survival; PFS, progression-free survival.
Article Title: Propensity score–weighted analysis of chemotherapy after PD-1 inhibitors versus chemotherapy alone in patients with non–small cell lung cancer (WJOG10217L)
Publication Title: Journal for ImmunoTherapy of Cancer -
Description VPA and vorinostat induce an ICD and downregulates anti-phagocytic CD47 in tumor cells. SKBR3 cells were treated with VPA or SAHA, for 24 hours. (A, B) Calreticulin (CALR) and (C, D) CD47...
Article Title: Histone deacetylase inhibitors valproic acid and vorinostat enhance trastuzumab-mediated antibody-dependent cell-mediated phagocytosis
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Examples of cancer immunotherapy-related measures in professional society sets
Article Title: Defining current gaps in quality measures for cancer immunotherapy: consensus report from the Society for Immunotherapy of Cancer (SITC) 2019 Quality Summit
Publication Title: Journal for ImmunoTherapy of Cancer