Asset Search
Displaying assets 1 - 30 of 487 in total.
-
Description Images describing the condition and therapeutic responses of patient C. a scheme shows the time course of patient A in diagnosis the therapy. b MRI images show the therapeutic response of patients...
Article Title: Local and abscopal responses in advanced intrahepatic cholangiocarcinoma with low TMB, MSS, pMMR and negative PD-L1 expression following combined therapy of SBRT with PD-1 blockade
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Cytokine regulation of the proliferation and cytotoxicity of primary NK cells.a CD3-CD56+ NK cells (0.6–1.8 × 106 / well) isolated from PBMCs were cultured in the indicated cytokines for 21 days....
Article Title: IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells
Publication Title: Journal for ImmunoTherapy of Cancer -
Description α-GalCer increases the frequency of NKT cells, IFN-γ secretion, and inhibits tumor growth. Naïve C57BL6 mice were given s.c. injection of B16F10 cells (1 X 106 cells/mouse), and animals were also...
Article Title: Natural killer T cell activation increases iNOSCD206 M1 macrophage and controls the growth of solid tumor
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Graphical abstract.
Article Title: Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Stable IDO1 overexpression enhances xenograft tumor growth in BALB/c mice. a Average growth curves of subcutaneous xenograft tumors in BALB/c mice after inoculation of CT26 cells with stable IDO1...
Article Title: miR-448 targets IDO1 and regulates CD8 T cell response in human colon cancer
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Effect of H5B14-based ADCs on cancer stem cell-derived spheroid formation, cellular viability, and ALDH expression. a Inhibitory effect of H5B14-based ADCs on spheroid formation by pancreatic...
Article Title: Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Multivariate analyses of prognostic factors correlated with PFS and OS
Article Title: HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Immunomonitoring of lymphoid cells and myeloid cells after radiotherapy. Ten days after the injection of CT26 colon murine cancer, mice were assigned in 4 groups: control (at day 7), 1×16.4Gy...
Article Title: Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Clinical trials in glioma or glioblastoma targeting activators of effector T cells
Article Title: T lymphocyte-targeted immune checkpoint modulation in glioma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Safety profiles of anti-PD-1 monotherapy, chemotherapy alone, or their combination in advanced nasopharyngeal carcinoma. a Bar plot depicts the incidence rates of grade 1–5 adverse events (divided...
Article Title: Comparative safety and efficacy of anti-PD-1 monotherapy, chemotherapy alone, and their combination therapy in advanced nasopharyngeal carcinoma: findings from recent advances in landmark trials
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Changes of the immunopeptidome through IFNγ treatment (600 ng/ml for 48 h) in four PDOs. a Flow cytometric quantification of HLA-I molecules per cell with and without IFNγ treatment. b Number of...
Article Title: Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Clinical characteristics of the study population
Article Title: Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3
Publication Title: Journal for ImmunoTherapy of Cancer -
Description STAT3/ARG1 signaling is up-regulated in suppressive monocytes. a p-STAT3 detection in suppressive (n = 4) and non-suppressive (n = 4) PDAC patients’ monocytes was evaluated by flow cytometry....
Article Title: Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Efficacy of α-PD-1 therapy of tongue-implanted mEER tumors is enhanced by combination treatment with α-CTLA-4 but not α-Lag3. Mice were challenged with mEER tumor cells (4 × 104) in the tongue and...
Article Title: Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV oral cancer
Publication Title: Journal for ImmunoTherapy of Cancer -
Description a-GalCer-treated mice show a higher frequency of M1 macrophages and low tumor growth. Naïve C57BL6 mice were given s.c. injection of B16F10 cells (1 X 106 cells/mouse) and animals were treated with...
Article Title: Natural killer T cell activation increases iNOSCD206 M1 macrophage and controls the growth of solid tumor
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Changes in tumorigenicity of hetero-spheroids in vivo in NSG mice. Tumors were generated in NSG mice from CSC mono-spheroids, or CSCs isolated from hetero-spheroids in CSC/M2 or CSC/shWNT5b M2. a...
Article Title: Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Multivariate Cox regression analysis of overall survival in the study population
Article Title: Impact of antibiotic therapy on the development and response to treatment of immune checkpoint inhibitor-mediated diarrhea and colitis
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Ovarian cancer stem cells and macrophages reciprocally interact through the Wnt pathway to promote a pro-tumoral microenvironment. Our data suggests that in hetero-spheroids, CSCs drive a CD206+...
Article Title: Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments
Publication Title: Journal for ImmunoTherapy of Cancer -
Description VPA downregulates the anti-apoptotic protein MCL1 in tumor cells. SKBR3 cells were treated with VPA or SAHA, for 24 hours. (A) MCL1 expression determined by FCM. corresponding overlay histograms...
Article Title: Histone deacetylase inhibitors valproic acid and vorinostat enhance trastuzumab-mediated antibody-dependent cell-mediated phagocytosis
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Dot plots for antitumor immune gene expression signatures. CUP cohort (n = 72) was compared with the Prat cohort of ICI-treated solid cancers (n = 63). a–d Gene signatures for CD8+ effector T...
Article Title: Clinical and immune profiling for cancer of unknown primary site
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Accuracy outperformed correlation in assessing the performance of panel-based tumor mutational burden (TMB) estimation. a Changes in the correlation and accuracy when successively removing the...
Article Title: Designing gene panels for tumor mutational burden estimation: the need to shift from ‘correlation’ to ‘accuracy’
Publication Title: Journal for ImmunoTherapy of Cancer -
Description IGET induced tumor regression depended on adaptive immune response and not due to a direct effect of plasmid DNA. Nude mice (a and b) and TLR9−/− mice (c and d) were intradermally injected with 0.5...
Article Title: Pre-clinical investigation of the synergy effect of interleukin-12 gene-electro-transfer during partially irreversible electropermeabilization against melanoma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Ongoing clinical trials in further lines of treatment for SCLC
Article Title: Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Identification of CD4+ T-cell clusters in Tumor Infiltrating T-cell populations (a) Heatmap of all CD4+ T-cell clusters identified at day 8 after the start of the PD-L1 treatment. Data shown is...
Article Title: PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors
Publication Title: Journal for ImmunoTherapy of Cancer -
Description a CT scan after treatment with an RNA oligonucleotide drug, MTL-CEBPA; 4.0 cm liver lesion b CT scan showing partial response after treatment with Lenvatinib for 8 weeks; 2.6 cm liver lesion c CT...
Article Title: Response to targeted therapy or chemotherapy following immunotherapy in patients with gastrointestinal cancers - a case series
Publication Title: Journal for ImmunoTherapy of Cancer -
Description IFNα and IFNβ-activated STAT3 binds to the Gzmb promoter in CTLs. a. Structures of the Gzmb promoter. The six putative ISRE sequences (right panel) and locations (left panel) are shown. b. Resting...
Article Title: Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes
Publication Title: Journal for ImmunoTherapy of Cancer -
Description DIRE cases. a Literature review to identify DIRE cases – immune-related adverse events presenting ≥90 days after discontinuation of immunotherapy
Article Title: Delayed immune-related events (DIRE) after discontinuation of immunotherapy: diagnostic hazard of autoimmunity at a distance
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Individual Patient Baseline Characteristics and Response to Treatment with Pembrolizumab
Article Title: Phase II clinical trial of pembrolizumab efficacy and safety in advanced adrenocortical carcinoma
Publication Title: Journal for ImmunoTherapy of Cancer -
Description HLA-I immunopeptidome in five PDOs. a Number of unique peptides detected per PDO. b Number of source proteins to which peptides from A uniquely mapped. c Correlation of HLA-I molecules per cell...
Article Title: Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment
Publication Title: Journal for ImmunoTherapy of Cancer -
Description Univariate and multivariate regression analysis of disease-free survival in each data set
Article Title: Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung cancer
Publication Title: Journal for ImmunoTherapy of Cancer
Displaying assets 1 - 30 of 487 in total.