Description Complete disappearance of origin and disseminated abscesses. Left panel, computed tomography on admission or day 7; right panel, computed tomography on day 96.
Article Title: Case of disseminated pyomyositis in poorly controlled type 2 diabetes mellitus with diabetic ketoacidosis
Publication Title: Journal of Diabetes Investigation

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Description Flow diagram of inclusion and exclusion criteria in the Isfahan Diabetes Prevention Study. A total of 1,865 individuals were finally included. T2D, type 2 diabetes.
Article Title: Utility of hypertriglyceridemic waist phenotype for predicting incident type 2 diabetes: The Isfahan Diabetes Prevention Study
Publication Title: Journal of Diabetes Investigation

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Description The changes in plasma glycated hemoglobin (HbA1c) level after randomization. Open circles denote the metformin plus mitiglinide group and closed circles denote the metformin plus placebo group. *P...
Article Title: Effect of the combination of mitiglinide and metformin on glycemic control in patients with type 2 diabetes mellitus
Publication Title: Journal of Diabetes Investigation

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Description Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort studyLipid ratio and risk of...
Article Title: Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study
Publication Title: Journal of Diabetes Investigation

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Description Plasma pancreatic‐derived factor (PANDER; ng/mL) in participants with normal glucose tolerance (NGT; n = 149), impaired glucose tolerance (IGT; n = 40) and diabetes mellitus (DM; n = 23). *P < 0.05.
Article Title: Elevated circulating level of a cytokine, pancreatic‐derived factor, is associated with metabolic syndrome components in a Chinese population
Publication Title: Journal of Diabetes Investigation

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Description Receiver operating characteristic (ROC) curves establishing cut‐off levels between controls and type 2 diabetic patients for the period until complete color change of the Neuropad and the...
Article Title: Correlation between sudomotor function, sweat gland duct size and corneal nerve fiber pathology in patients with type 2 diabetes mellitus
Publication Title: Journal of Diabetes Investigation

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Description Secretion and metabolism of glucose‐dependent insulinotropic polypepide (GIP) and glucagon‐like peptide (GLP)‐1. GIP is secreted from K cells of the upper intestine; GLP‐1 is secreted from L cells...
Article Title: GIP and GLP‐1, the two incretin hormones: Similarities and differences
Publication Title: Journal of Diabetes Investigation

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Description Knockdown of sorting nexin 19 (SNX19) decreased the number of dense core vesicles (DCV). (a) Representative electron micrographs of 15 images in control, sorting nexin 19 knockdown (SNX19KD)1 and...
Article Title: Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β‐cells
Publication Title: Journal of Diabetes Investigation

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Description Funnel plot with Egger's regression line for risk ratio of type 2 diabetes (T2D). lnRR, ln(relative risk).
Article Title: Association between omega‐3 fatty acids consumption and the risk of type 2 diabetes: A meta‐analysis of cohort studies
Publication Title: Journal of Diabetes Investigation

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Description Immunohistochemical detection of proliferating cells in the islet doubly stained with insulin (red) and Ki67 (brown) in experimental animals. In normal Wistar rats (W) and GK rats (GK) at this age,...
Article Title: Augmented reduction of islet β‐cell mass in Goto‐Kakizaki rats fed high‐fat diet and its suppression by pitavastatin treatment
Publication Title: Journal of Diabetes Investigation

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Description Changes of cardio‐ankle vascular index (CAVI) in subdivided groups by the (a) improvement of hemoglobin A1c (HbA1c) or (b) change of total cholesterol are shown. 1st, first measurement of CAVI...
Article Title: Increased arterial stiffness is closely associated with hyperglycemia and improved by glycemic control in diabetic patients
Publication Title: Journal of Diabetes Investigation

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Description Concentrations of (a) plasma glucose (PG), (b) serum insulin (IRI) and (c) serum C‐peptide (CPR) during the 75 g oral glucose tolerance test (OGTT; closed circle), 17 g OGTT (closed square) and...
Article Title: Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance
Publication Title: Journal of Diabetes Investigation

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Description Correlations between (a) predicted and measured glycated albumin (GA), and (b) predicted and measured glycated hemoglobin (A1C) at the third visit. Using the equations with GA and A1C before the...
Article Title: Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes
Publication Title: Journal of Diabetes Investigation

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Description Mean glycated albumin (GA) by donor age. Closed circles indicate GA (%) in the male group, and open circles indicate GA (%) in the female group.
Article Title: Introduction of glycated albumin measurement for all blood donors and the prevalence of a high glycated albumin level in Japan
Publication Title: Journal of Diabetes Investigation

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Description Messenger ribonucleic acid (mRNA) expression levels in HepG2 cells were measured 24 h after transfection with microribonucleic acid‐29 (microRNA29) mimic. (a) Measurement of microRNA29 expression;...
Article Title: Correlation analysis of microribonucleic acid‐155 and microribonucleic acid‐29 with type 2 diabetes mellitus, and the prediction and verification of target genes
Publication Title: Journal of Diabetes Investigation

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Description (a) Effects of exenatide once‐weekly (EQW) or exenatide twice daily (EBID) on bodyweight over the 26‐week treatment period. *P < 0.05; *P < 0.001, EQW vs EBID. (b) Scatterplot of change in...
Article Title: Efficacy and safety of exenatide once‐weekly vs exenatide twice‐daily in Asian patients with type 2 diabetes mellitus
Publication Title: Journal of Diabetes Investigation

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Description Landmark studies showing the effectiveness of renin–angiotensin system inhibitors on diabetic kidney disease, and cardiovascular mortality and morbidity.
Article Title: Therapeutic management of diabetic kidney disease
Publication Title: Journal of Diabetes Investigation

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Description Lifestyle intervention significantly reduced overall adiposity as measured by (a) bodyweight and (b) underwater weighing at 6 and 24 months compared with control. Lifestyle intervention also...
Article Title: Risk factors for type 2 diabetes: Lessons learned from Japanese Americans in Seattle
Publication Title: Journal of Diabetes Investigation

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Description Scatter plots for the relationship between baseline hemoglobin A1c (HbA1c) and the change in HbA1c from baseline to the end of treatment in the placebo (n = 321, r = 0.004, P = 0.942) and...
Article Title: Efficacy and safety of ipragliflozin in Japanese patients with type 2 diabetes stratified by body mass index: A subgroup analysis of five randomized clinical trials
Publication Title: Journal of Diabetes Investigation

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Description The mRNA expression levels of various genes in AR42J cells incubated with exendin‐4 and/or gastrin. AR42J cells were incubated for 3 days with exendin‐4 (1 nmol/L) and/or gastrin (10 nmol/L)....
Article Title: Combination treatment of db/db mice with exendin‐4 and gastrin preserves β‐cell mass by stimulating β‐cell growth and differentiation
Publication Title: Journal of Diabetes Investigation

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Description Characterization of MIN6‐K8 and MIN6‐K20 cells. (a) Morphology of K8 and K20 cells. Cells were grown as monolayers on a tissue culture dish in DMEM containing 25 mmol/L glucose (scale bars, 100...
Article Title: Establishment of new clonal pancreatic β‐cell lines (MIN6‐K) useful for study of incretin/cyclic adenosine monophosphate signaling
Publication Title: Journal of Diabetes Investigation

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Description Subgroup meta‐analysis for adiponectin levels in prediabetes patients and healthy controls by geographic region. Calculation based on random effects model. Results are expressed as weighted mean...
Article Title: Association between the level of circulating adiponectin and prediabetes: A meta‐analysis
Publication Title: Journal of Diabetes Investigation

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Description Change from baseline in (a) tartrate‐resistant acid phosphatase‐5 levels (TRACP‐5b) and (b) bone alkali phosphatase levels (BAP) after 12 and 24 weeks of treatment with ipragliflozin and metformin....
Article Title: Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type 2 diabetes mellitus: Subanalysis of a prospective, randomized, controlled study (PRIME‐V study)
Publication Title: Journal of Diabetes Investigation

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Description Ex‐4 treatment increased insulin‐positive areas, number of islets and insulin content. (a–d) Representative mouse pancreata at 5 weeks‐of‐age stained with insulin. (a) Wild, (b) Akita mice treated...
Article Title: GLP‐1 receptor agonist attenuates endoplasmic reticulum stress‐mediated β‐cell damage in Akita mice
Publication Title: Journal of Diabetes Investigation

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Description Effect of therapeutic administration of FTY720 alone or in combination with insulin glargine on fasting blood glucose levels in NOD mice with overt type 1 diabetes mellitus (DM). Female NOD mice...
Article Title: Therapeutic approach for type 1 diabetes mellitus using the novel immunomodulator FTY720 (fingolimod) in combination with once‐daily injection of insulin glargine in non‐obese diabetic mice
Publication Title: Journal of Diabetes Investigation

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Description Immunohistochemical detection of apoptotic cells in the islet stained with ApopTag in experimental animals. In normal Wistar rats (W) and GK rats (GK), apoptotic cells were rarely detected. Absence...
Article Title: Augmented reduction of islet β‐cell mass in Goto‐Kakizaki rats fed high‐fat diet and its suppression by pitavastatin treatment
Publication Title: Journal of Diabetes Investigation

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Description Funnel plot of relative risk (logarithms of relative risk [lnRR]) of type 2 diabetes mellitus (T2DM) for the least stable category compared with the most stable category of bodyweight in relation...
Article Title: Unstable bodyweight and incident type 2 diabetes mellitus: A meta‐analysis
Publication Title: Journal of Diabetes Investigation

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Description The role of pyruvate dehydrogenase kinase (PDK) in immune cell metabolism. (a) Enhancement in PDK activity increases aerobic M1 (M1 macrophage), CD8+ T cells and CD4+ T cells (T‐helper 1 or...
Article Title: Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
Publication Title: Journal of Diabetes Investigation

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Description Forest plots of the relationship between TCF7L2 rs7903146 polymorphism and the risk of gestational diabetes mellitus across different populations. Black diamonds denote the pooled odds ratio. Blue...
Article Title: Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta‐analysis
Publication Title: Journal of Diabetes Investigation

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Description Exogenous 2,2′‐(hydroxynitrosohydrazino)bis‐ethanamine (NOC; 1 U/kg/day) treatments (a) significantly restored the suppressive effect of diabetes on urinary NO2 + NO3 levels and (b) downregulated...
Article Title: Nitric oxide donors rescue diabetic nephropathy through oxidative‐stress‐ and nitrosative‐stress‐mediated Wnt signaling pathways
Publication Title: Journal of Diabetes Investigation

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