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Description Distribution of fasting serum C‐peptide immunoreactivity (CPR) levels in patients with acute‐onset type 1 diabetes. (a) Histogram. (b) Box plot.
Article Title: Diagnostic criteria for acute‐onset type 1 diabetes mellitus (2012): Report of the Committee of Japan Diabetes Society on the Research of Fulminant and Acute‐onset Type 1 Diabetes Mellitus
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12612-fig-0003
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Forest plots of the relationship between TCF7L2 rs12255372 polymorphism and the risk of gestational diabetes mellitus across different populations. Black diamonds denote the pooled odds ratio. Blue...
Article Title: Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta‐analysis
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12266-fig-0001
- License Type
- CC-BY-NC-ND
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Study design. Visits were scheduled every 4 weeks during the treatment period.
Article Title: Efficacy and safety of canagliflozin alone or as add‐on to other oral antihyperglycemic drugs in Japanese patients with type 2 diabetes: A 52‐week open‐label study
Publication Title: Journal of Diabetes Investigation -
Description The relationship between binding of ligands to the pattern recognition advance glycation end‐product receptor (RAGE), and inflammation, gene expression, oxidative and nitrosative stress, and damage...
Article Title: Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease
Publication Title: Journal of Diabetes Investigation -
Description Schematic illustration of renal function and lupus activity. Platelet number (Plt) and complement (C3) level gradually returned to near normal after the addition of cyclosporine, suggesting...
Article Title: Efficacy of oral glucocorticoid and cyclosporine in a case of rituximab‐refractory type B insulin resistance syndrome
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12720-tbl-0002
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Parameters of comprehensive fat content analysis for the study participants
Article Title: Pancreatic fat content assessed by 1H magnetic resonance spectroscopy is correlated with insulin resistance, but not with insulin secretion, in Japanese individuals with normal glucose tolerance
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12622-fig-0002
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Relationships between (a) glucose at 0 min (G0) and mannose at 0 min (M0), (b) Quantitative Insulin Sensitivity Check Index (QUICKI) and M0, (c) glucose at 120 min (G120) and plasma mannose changes...
Article Title: Plasma mannose level, a putative indicator of glycogenolysis, and glucose tolerance in Japanese individuals
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12399-fig-0001
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Mean glucose infusion rate profiles for insulin degludec (IDeg) at steady state in Japanese patients with type 1 diabetes.
Article Title: Pharmacokinetic and pharmacodynamic properties of insulin degludec in Japanese patients with type 1 diabetes mellitus reflect similarities with Caucasian patients
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12366-fig-0002
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Plasma levels of mitochondrial deoxyribonucleic acid (mtDNA) correlate with the levels of fasting blood glucose (FBG; r = 0.323, P < 0.05) in coronary heart disease patients with diabetes mellitus.
Article Title: Circulating cell‐free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus
Publication Title: Journal of Diabetes Investigation -
Description Glucose measurement interference after administration of various concentrations of ascorbic acid. Glucose concentrations were measured using Medisafe® (diamond symbols) and Glucocard® (triangular...
Article Title: Pseudohypoglycemia or hyperglycemia caused by interference with self‐monitoring blood glucose measurements in anticancer ascorbic acid therapy
Publication Title: Journal of Diabetes Investigation -
Description Changes in intramyocellular lipid (IMCL) and glucose infusion rate (GIR) during euglycemic hyperinsulinemic glucose clamp study in a high‐fat diet. (a) IMCL level in the tibialis anterior muscle...
Article Title: Determinants of intramyocellular lipid accumulation after dietary fat loading in non‐obese men
Publication Title: Journal of Diabetes Investigation -
Description Concept of metabolic syndrome according to its major clinical outcome. (a) Classical concept of metabolic syndrome including type 2 diabetes as one of the main components. (b) Proposed concept that...
Article Title: Metabolic syndrome as a predictor of type 2 diabetes, and its clinical interpretations and usefulness
Publication Title: Journal of Diabetes Investigation -
Description (a) Mean pancreatic computed tomography (CT) values were significantly positively correlated with insulinogenic index (II) in multiple regression analysis (r = 0.247, P < 0.01). (b) Insulinogenic...
Article Title: Insulin secretion and computed tomography values of the pancreas in the early stage of the development of diabetes
Publication Title: Journal of Diabetes Investigation -
Description β‐Cell specific expression of green fluorescent protein (GFP)‐tagged human proinsulin in transgenic zebrafish. (a) Schematic diagram of transgene construct used to drive expression of Cpep‐GFP or...
Article Title: Transgenic zebrafish model of the C43G human insulin gene mutation
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12296-fig-0001
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Time‐course of changes in urinary albumin excretion (U‐Alb/Cr), estimated glomerular filtration rate (eGFR), serum cystatin C (CysC) and estimated glomerular filtration rate using serum cystatin C...
Article Title: Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy
Publication Title: Journal of Diabetes Investigation -
Description Percent inhibition of plasma dipeptidyl peptidase‐4 (DPP‐4) activity from baseline after (a) single and (b) multiple dose administration of omarigliptin or placebo in healthy Japanese men. Data are...
Article Title: Single and multiple dose pharmacokinetics and pharmacodynamics of omarigliptin, a novel, once‐weekly dipeptidyl peptidase‐4 inhibitor, in healthy Japanese men
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12305-fig-0003
- License Type
- CC-BY-NC-ND
- Rights Holder
- Creative Commons by John Wiley & Sons
Description The theoretical glucose‐lowering effects of therapies augmenting insulin secretion according to the different baseline insulin secretion and insulin sensitivity. This figure is drawn with an...
Article Title: Incretin physiology and pathophysiology from an Asian perspective
Publication Title: Journal of Diabetes Investigation -
Description Lifestyle intervention significantly improved (a) insulin sensitivity at 6 and 24 months compared with control, but had no effect upon (b) beta‐cell function. P‐values for control vs intervention...
Article Title: Risk factors for type 2 diabetes: Lessons learned from Japanese Americans in Seattle
Publication Title: Journal of Diabetes Investigation -
Description Sirtuin 1 (SIRT1)‐mediated metabolic responses. In the liver, SIRT1 regulates hepatic glucose production through peroxisome proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1α), forkhead box...
Article Title: Sirtuin 1 as a key player of ‘metabolic memory’
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12545-fig-0001
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Schematic representation of the possible role of the polyol pathway in diabetes atherosclerosis. The polyol pathway consists of two steps: glucose is first reduced to sorbitol by the enzyme, aldose...
Article Title: Pathogenesis and neuroimaging of cerebral large and small vessel disease in type 2 diabetes: A possible link between cerebral and retinal microvascular abnormalities
Publication Title: Journal of Diabetes Investigation -
Description Comparison of SDG‐P and SDG‐R mice with C57BL/6J. (a) An oral glucose tolerance test (OGTT) was performed in male SDG‐P (G14, n = 5), SDG‐R (G13, n = 5) and C57BL/6J (n = 7) mice at 10 weeks of...
Article Title: Selective breeding of mice for different susceptibilities to high fat diet‐induced glucose intolerance: Development of two novel mouse lines, Selectively bred Diet‐induced Glucose intolerance‐Prone and ‐Resistant
Publication Title: Journal of Diabetes Investigation -
Description Vascular unit model proposed by Harel et al. (reproduced with permission from Frontiers in Neuroenergetics). The (a) circular nature of the vascular organization is shown in a cross‐section showing...
Article Title: Extension of the mitochondria dysfunction hypothesis of metabolic syndrome to atherosclerosis with emphasis on the endocrine‐disrupting chemicals and biophysical laws
Publication Title: Journal of Diabetes Investigation -
Description Risk of bias evaluation graph.
Article Title: Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi13327-tbl-0003
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Table
Article Title: Effect of the FreeStyle Libre™ flash glucose monitoring system on glycemic control in individuals with type 2 diabetes treated with basal–bolus insulin therapy: An open label, prospective, multicenter trial in Japan
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi13336-tbl-0003
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Table
Article Title: Relationships between time in range, glycemic variability including hypoglycemia and types of diabetes therapy in Japanese patients with type 2 diabetes mellitus: Hyogo Diabetes Hypoglycemia Cognition Complications study
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12648-fig-0001
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Clinical time‐course. Increased serum thyroid hormones and decreased thyroid‐stimulating hormone (TSH) were observed on admission. Two weeks later, the patient's thyroid hormone levels were within...
Article Title: Aggravation of type 2 diabetes mellitus triggered by acute exacerbation of chronic thyroiditis (Hashimoto's disease)
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12554-fig-0001
- License Type
- CC-BY-NC-ND
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Comparison of all‐cause mortality among four groups classified into brachial‐ankle pulse wave velocity (baPWV; above or below the median [21.8 m/s]) and ankle‐brachial pressure index (ABI; normal...
Article Title: Brachial‐ankle pulse wave velocity, but not ankle‐brachial index, predicts all‐cause mortality in patients with diabetes after lower extremity amputation
Publication Title: Journal of Diabetes Investigation -
Description Signaling pathways proposed to be involved in proximal events in glucose‐dependent insulinotropic polypeptide (GIP)‐mediated potentiation of glucose‐induced insulin secretion. (a) Evidence has been...
Article Title: Glucose‐dependent insulinotropic polypeptide signaling in pancreatic β‐cells and adipocytes
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12677-fig-0003
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Meta‐regression on hazard ratios of all‐cause mortality for (a) age, as well as (b) follow‐up duration in overweight and obese patients vs normal weight patients (the size of the circles represents...
Article Title: Impact of obesity on mortality in patients with diabetes: Meta‐analysis of 20 studies including 250,016 patients
Publication Title: Journal of Diabetes Investigation -
- Identifier
- jdi12270-fig-0002
- License Type
- CC-BY-NC-ND
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Approximate entropy (ApEn) curves from diabetes patients showing the low‐frequency component (LF), total heart rate variability (Total), high‐frequency component (HF), very low frequency component...
Article Title: Cardiovascular autonomic function analysis using approximate entropy from 24‐h heart rate variability and its frequency components in patients with type 2 diabetes
Publication Title: Journal of Diabetes Investigation