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Description Lck kinase functions upstream of c‐Abl. (A) Jurkat T cells were treated with sulfatides for indicated times before being lysed, the lysates were prepared as described, and the immunoblots were...
Article Title: Critical role of Lck in L‐selectin signaling induced by sulfatides engagement
Publication Title: Journal of Leukocyte Biology -
Description Phagocytosis of nonopsonized zymosan, IgG‐opsonized zymosan, and serum‐opsonized zymosan by PMA‐differentiated THP‐1 cells deficient in PI‐3K p110α subunit. (A) Western blot analysis of Class IA...
Article Title: Monocyte p110α phosphatidylinositol 3‐kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production
Publication Title: Journal of Leukocyte Biology -
Description Gr1+CD11b+ cells generated in C/EBPβ cKO mice undergoing sepsis had significantly less CD31+ cells and did not exhibit immunosuppressive phenotypes. Gr1+CD11b+ cells were isolated from the bone...
Article Title: Frontline Science: Myeloid cell‐specific deletion of Cebpb decreases sepsis‐induced immunosuppression in mice
Publication Title: Journal of Leukocyte Biology -
Description Differential levels of CB2 mRNA are detected in neonatal rat brain cerebral cortex microglia in relation to cell activation state. (A) Southern blot of mutagenic reverse transcriptase‐polymerase...
Article Title: Cannabinoid receptors in microglia of the central nervous system: immune functional relevance
Publication Title: Journal of Leukocyte Biology -
Description Effect of PGE2 and CAY10399 on fMLP‐induced Akt phosphorylation. PMNs were preincubated for 10 min with 10−5 M PGE2 or 10−5 M CAY10399 and stimulated with 100 nM fMLP for the times indicated. The...
Article Title: Dissociation between the translocation and the activation of Akt in fMLP‐stimulated human neutrophils—effect of prostaglandin E2
Publication Title: Journal of Leukocyte Biology -
Description Enzymatic activity of Akt in fMLP‐stimulated PMNs. PMN suspensions (2×107 cell/ml) were preincubated with 0.1 U/ml ADA (5 min), with 10 μM H‐89 for an additional 5 min, and with 10−5 M PGE2 or...
Article Title: Dissociation between the translocation and the activation of Akt in fMLP‐stimulated human neutrophils—effect of prostaglandin E2
Publication Title: Journal of Leukocyte Biology -
Description Pyk2 controls the turnover of lineage‐traced Ly6C− BM monocytes. (A) The in vivo proliferative capacity of BM cMoPs, Ly6C+, and Ly6C− monocytes was assessed after a 2‐h i.p. BrdU pulse....
Article Title: The nonreceptor protein tyrosine kinase Pyk2 promotes the turnover of monocytes at steady state
Publication Title: Journal of Leukocyte Biology -
Description CLU synergizes with IL‐2 for the proliferation of NK cells. (A) Purified NK cells were plated at 1 × 105 cells/well and incubated for 3 days with various concentrations of IL‐2 (10, 100, 500, and...
Article Title: Clusterin synergizes with IL‐2 for the expansion and IFN‐γ production of natural killer cells
Publication Title: Journal of Leukocyte Biology -
Description Exogenous IL‐2 prevents the induction of T cell hyporesponsiveness (A) but does not abrogate T cell anergy once it has been induced by MPA‐DC (B). (A) First coculture of allogeneic CD4+ T cells...
Article Title: Induction of human CD4+ regulatory T cells by mycophenolic acid‐treated dendritic cells
Publication Title: Journal of Leukocyte Biology -
Description Representative Western blots showing the effects of T0901317 on IκB‐α degradation and NF‐κBp65 expression and on MAPK signal transduction pathway after SAO shock. Basal expression of IκB‐α was...
Article Title: Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury
Publication Title: Journal of Leukocyte Biology -
Description Proliferation of cord blood and adult blood CD8 T cells in relation to KIR expression. The population of NK and T cells isolated from blood was labeled with CFSE prior to culture in medium...
Article Title: CD8 T cells expressing killer Ig‐like receptors and NKG2A are present in cord blood and express a more naïve phenotype than their counterparts in adult blood
Publication Title: Journal of Leukocyte Biology -
Description TNF‐α‐induced maintenance of O2•– levels in monocytes is regulated via the NF‐κB pathway. (A) Human blood monocytes were isolated and treated with buffer (▪, □) or 3 μM IKK Inhibitor III (•) for 1...
Article Title: Role of NF‐κB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor‐α
Publication Title: Journal of Leukocyte Biology -
Description Effect of chronic ethanol consumption on phenotypes and numbers of pancreatic mononuclear inflammatory cells after infection with CVB3‐CO. Mononuclear cells were obtained from mice provided ethanol...
Article Title: Alcoholic pancreatitis: mechanisms of viral infections as cofactors in the development of acute and chronic pancreatitis and fibrosis
Publication Title: Journal of Leukocyte Biology -
Description Effect of the synthetic serine Pi AAPV‐CMK on cytokine production in diluted and S. epi‐ stimulated whole blood, which was diluted 1:16 in RPMI (Control), diluted 1:16 in RPMI and stimulated with...
Article Title: α‐1‐Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood
Publication Title: Journal of Leukocyte Biology -
Description Basophils infiltrating the skin lesions of IgE‐mediated, chronic, allergic inflammation express mMCP‐11 proteins. Mast cell‐deficient (C57BL/6‐Kitw‐sh/wsh) mice (A) and wild‐type C57BL/6 mice (B...
Article Title: Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells
Publication Title: Journal of Leukocyte Biology -
Description IL‐1ra, anakinra, treatment attenuates the effect of alcohol‐feeding on caspase‐1 activity and IL‐1β production in murine cerebella. WT mice were fed with a PF or an EtOH diet for 5 weeks and...
Article Title: Alcohol‐induced IL‐1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation
Publication Title: Journal of Leukocyte Biology -
Description Bacteriology at Days 3 and 10 postinfection. BALF and whole lung homogenate were obtained from Cftrfl10, Cftrfl10 + LysMCre, and Cftrtm1Unc mice and controls and cultured for P. aeruginosa growth...
Article Title: Absence of the cystic fibrosis transmembrane regulator (Cftr) from myeloid‐derived cells slows resolution of inflammation and infection
Publication Title: Journal of Leukocyte Biology -
Description The mechanisms of inhibitory effects of Tregs during chronic HCV infection. Tregs use direct cell–cell contact (via PD‐1 and other surface molecules, such as CTLA‐4 and GITR) and soluble inhibitory...
Article Title: T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't
Publication Title: Journal of Leukocyte Biology -
Description Down‐regulation of individual PKC isoforms with antisense oligonucleotides alters LPS‐stimulated secretion of IL‐12p40 and TNF‐α. (A) Western blot of whole cell lysates from macrophages treated...
Article Title: Role of PKC isoforms in the FcγR‐mediated inhibition of LPS‐stimulated IL‐12 secretion by macrophages
Publication Title: Journal of Leukocyte Biology -
Description rCRP‐induced chemokine secretion depends on the CD11b/ICAM‐1 interaction. Effect of anti‐CD11b or anti‐ICAM‐1 antibodies alone or in combination with anti‐CD32a, anti‐CD32b, and anti‐CD64...
Article Title: C‐reactive protein (CRP) induces chemokine secretion via CD11b/ICAM‐1 interaction in human adherent monocytes
Publication Title: Journal of Leukocyte Biology -
Description TNF‐α + PGE2 do not detectably activate Stat1 or autocrine IFN‐β production. Human monocyte‐derived, immature DCs were stimulated with 10 ng/ml LPS, TNF‐α (25 ng/ml), PGE2 (1 ng/ml), or TNF‐α +...
Article Title: Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF‐α and PGE2
Publication Title: Journal of Leukocyte Biology -
Description Binding of hMFG‐E8 to phosphatidylserine and integrin αvβ3. (A) Binding to phosphatidylserine. (Left) A microtiter plate was coated with phosphatidylserine and incubated with the indicated...
Article Title: Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus
Publication Title: Journal of Leukocyte Biology -
Description The balance of LN PDC IL‐10:IL‐12 and IL‐4:IFN‐γ expression differs between two breast cancer prognostic groups. The balance of IL‐10:IL‐12 (A) and IL‐4:IFN‐γ (B) expression was compared among our...
Article Title: Plasmacytoid dendritic cells (PDC) are the major DC subset innately producing cytokines in human lymph nodes
Publication Title: Journal of Leukocyte Biology -
Description Anti‐CD44v7 efficiently mobilizes hematopoietic progenitor cells. CD44v7+/+ 129SV mice received three intravenous injections of PBS, 200 μg control IgG or anti‐CD44v7. BMC (A), SC (B), and PBMC (C)...
Article Title: Importance of CD44v7 isoforms for homing and seeding of hematopoietic progenitor cells
Publication Title: Journal of Leukocyte Biology -
Description Hyp‐DCHA inhibits chemotaxis through gelatin and Matrigel and MMP‐9 secretion by activated T cells. The modified Boyden chamber assay shows that lymphocyte chemotaxis toward CXCL10, through a...
Article Title: Hyperforin down‐regulates effector function of activated T lymphocytes and shows efficacy against Th1‐triggered CNS inflammatory‐demyelinating disease
Publication Title: Journal of Leukocyte Biology -
Description Effect of caspase inhibition on DC differentiation. A representative experiment in which DC and DC‐M cultures were established in the presence of wortmannin, Z‐IETD‐FMK (caspase 8 inhibitor),...
Article Title: Modulation of dendritic cell differentiation by colony‐stimulating factor‐1: role of phosphatidylinositol 3′‐kinase and delayed caspase activation
Publication Title: Journal of Leukocyte Biology -
Description Presence of MC3‐R on peritoneal Mø by Western blotting. Right‐hand panel shows immunoreactive MC3‐R detected in Swiss albino (SA) and C57.bl6 (C57) strains of murine and SD rats (Rat) naïve...
Article Title: Natural and synthetic agonists of the melanocortin receptor type 3 possess anti‐inflammatory properties
Publication Title: Journal of Leukocyte Biology -
Description This scattergram shows the correlation between levels of HIV replication in 3‐day‐old macrophages within identical twin pairs (twin 1 vs. twin 2) measured as intracellular HIV DNA by...
Article Title: The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes
Publication Title: Journal of Leukocyte Biology -
Description Colon histopathology is more severe in DSS treated in PPARγΔDC mice. Colons were removed at the termination of studies from mice killed, and tissue sections for Lines 1 and 2 were prepared and...
Article Title: Regulation of the mucosal phenotype in dendritic cells by PPARγ: role of tissue microenvironment
Publication Title: Journal of Leukocyte Biology -
Description Temporal relationship between IL‐10 and IL‐12 actions during S. aureus orthopedic implant biofilm infection. IL‐12 has a key role in MDSC recruitment during early biofilm infection via a...
Article Title: Interleukin‐10 production by myeloid‐derived suppressor cells contributes to bacterial persistence during Staphylococcus aureus orthopedic biofilm infection
Publication Title: Journal of Leukocyte Biology