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Description Production of IFN‐β in AtmLP/LP rats. (A–C) IHC for IFN‐β (brown reaction product) in hippocampus (A), cerebellum (B), and lumbar spinal cord (C). Original scale bars, ∼100 µm. (D) Quantification...
Article Title: Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage
Publication Title: Journal of Leukocyte Biology -
Description Cytokine production by DC populations following activation. DCs were stimulated with the indicated TLR ligands. Supernatants were collected after 24 h and were tested for the production of (A and...
Article Title: Polarization of naive T cells into Th1 or Th2 by distinct cytokine‐driven murine dendritic cell populations: implications for immunotherapy
Publication Title: Journal of Leukocyte Biology -
Description The mechanisms of inhibitory effects of Tregs during chronic HCV infection. Tregs use direct cell–cell contact (via PD‐1 and other surface molecules, such as CTLA‐4 and GITR) and soluble inhibitory...
Article Title: T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't
Publication Title: Journal of Leukocyte Biology -
Description Neutrophil depletion alters lung T cell responses during HMPV infection. BALB/c mice were treated with isotype (IgG) or test antibody (anti‐Ly6G) before and p.i. with HMPV. Lung single‐cell...
Article Title: Neutrophils regulate the lung inflammatory response via γδ T cell infiltration in an experimental mouse model of human metapneumovirus infection
Publication Title: Journal of Leukocyte Biology -
Description Change of NK ligands upon IFN‐γ or TNF treatment. (A) The expression of known ligands of activating NKRs and class I MHC molecules on THP‐1 cells. Untreated (dotted lines), IFN‐γ (50 ng/ml), or...
Article Title: Natural killer cell‐produced IFN‐γ and TNF‐α induce target cell cytolysis through up‐regulation of ICAM‐1
Publication Title: Journal of Leukocyte Biology -
Description Time‐dependent effects of LPS and TG on NO, TNF‐α, PGE2, and IL‐6 formation in macrophages. Cells were incubated with LPS (3 μg/mL), TG (30 nM), or both for different periods before assaying for...
Article Title: Involvement of protein kinases in the potentiation of lipopolysaccharide‐induced inflammatory mediator formation by thapsigargin in peritoneal macrophages
Publication Title: Journal of Leukocyte Biology -
Description Specificity of Vpr‐mediated inhibition of chemokine production in human primary PBLs. Normal human PBLs were purified as described in Materials and Methods and treated with 100 pg/ml concentration...
Article Title: HIV‐1 Vpr regulates expression of β chemokines in human primary lymphocytes and macrophages
Publication Title: Journal of Leukocyte Biology -
Description CCR4+Th+ cell trafficking in allergic airways inflammation. Sensitized guinea pigs (GP) were treated with IgG or anti‐CCR4 mAb 10E4 and were challenged with saline (open bars) or OVA (striped bars,...
Article Title: CCR4 blockade does not inhibit allergic airways inflammation
Publication Title: Journal of Leukocyte Biology -
Description Scheme of Hv1/VSOP function in neutrophils. On activation of NADPH oxidase stimulated by IgG in neutrophils, Hv1/VSOP supports O2− production. In contrast, this channel suppresses HOCl production...
Article Title: The voltage‐gated proton channel Hv1/VSOP inhibits neutrophil granule release
Publication Title: Journal of Leukocyte Biology -
Description CD26hi DC are specialized in the transport of apoptotic DNA and cytokeratin‐containing vesicles. Frozen cervical lymph cells were doubly labeled with CD1b and CD26, and cell subsets were sorted by...
Article Title: Enrichment for a CD26hi SIRP− subset in lymph dendritic cells from the upper aero‐digestive tract
Publication Title: Journal of Leukocyte Biology -
Description Purification of PC subsets from BCOLL and BMECH: Blimp‐1 and BSAP expression and IgVH6 gene mutations. (A) Dot plot histograms showing a representative CD20/CD38 staining of PCMECH and PCCOLL...
Article Title: Higher maturity and connective tissue association distinguish resident from ecently generated human tonsil plasma cells
Publication Title: Journal of Leukocyte Biology -
Description ANG production by HuMC following activation with TLR ligands. (A) HuMC were treated with LPS, PGN, CpG, and flagellin for 3 h, and ANG and β‐actin expression was analyzed by qRT‐PCR. (B) HuMC were...
Article Title: Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamily
Publication Title: Journal of Leukocyte Biology -
Description A1AT suppresses hemin‐induced HO‐1 gene and protein expression. Neutrophils were incubated for 5 h with medium alone, 1 mg/ml A1AT, 4 µM hemin, or 4 µM hemin plus 1 mg/ml A1AT. (A) Expression...
Article Title: Alpha1‐antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance
Publication Title: Journal of Leukocyte Biology -
Description Ligation of gC1qR on human MDDCs mediates specific suppression of TLR‐induced IL‐12p70 production. Human MDDCs (2×105) were stimulated for 8 h with 100 ng/mL LPS or 50 μg/mL poly(I:C) to induce DC...
Article Title: HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL‐12 production
Publication Title: Journal of Leukocyte Biology -
Description Effects of c‐RESV (1–100 μM) and the XO inhibitor allopurinol (10 μM) on production of uric acid by XO in the presence of 100 μM xanthine (A) or on O2•− production from xanthine as quantified by...
Article Title: Effects of cis‐resveratrol on inflammatory murine macrophages: antioxidant activity and down‐regulation of inflammatory genes
Publication Title: Journal of Leukocyte Biology -
Description Comparison of the fragments of vimentin detected by the different antivimentin antibodies and role of caspases in the degradation of intracellular vimentin in spontaneous or VAA‐I‐induced...
Article Title: Cell surface expression of intermediate filament proteins vimentin and lamin B1 in human neutrophil spontaneous apoptosis
Publication Title: Journal of Leukocyte Biology -
Description Localization of flavocytochrome b558 during phagocytosis appears similar in unstimulated and IFN‐γ‐prestimulated BMDMs. (A) Localization of 22YFP in 22YFP‐expressing, p22phox‐deficient BMDMs,...
Article Title: Effects of IFN‐γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558
Publication Title: Journal of Leukocyte Biology -
Description Endothelial expression of VCAM‐1 (A) and MAdCAM‐1 (B) in colonic vessels of colitic mice pretreated or treated with ic vehicle or ic TFF2. When compared with control animals, colitic mice showed a...
Article Title: Trefoil peptide TFF2 treatment reduces VCAM‐1 expression and leukocyte recruitment in experimental intestinal inflammation
Publication Title: Journal of Leukocyte Biology -
Description Tissue factor antigen accumulation in the developing arteriolar thrombus. (A) Tissue factor antigen fluorescence (blue) and the brightfield image of the cremaster muscle arteriole are composited...
Article Title: Leukocyte‐versus microparticle‐mediated tissue factor transfer during arteriolar thrombus development
Publication Title: Journal of Leukocyte Biology -
Description CD45+ cells coexpress CD31 from gd 5.5 to 9.5 in C57BL/6 implantation sites. (A) WM‐IHC of B6 implantation sites costained with anti‐CD45 APC (blue) and anti‐CD31 PE (red). CD31 expression was...
Article Title: Uterine natural killer cell partnerships in early mouse decidua basalis
Publication Title: Journal of Leukocyte Biology -
Description PD‐1 blockade prevents the sepsis‐induced loss in Bcl‐xL. Mice underwent sham or CLP surgery and 24 h later, had administration of anti‐PD‐1 antibody or isotype control antibody. At 48 h after...
Article Title: Delayed administration of anti‐PD‐1 antibody reverses immune dysfunction and improves survival during sepsis
Publication Title: Journal of Leukocyte Biology -
Description Effect of Cy3‐labeled CPDPs on fluorescence lifetime of Cer‐component (A) FLIM images of HeLa cells expressing Cerulean not fused to a TIR (upper row), Cer fused with the MyD88 (middle row), or...
Article Title: Frontline Science: Targeting the TLR7 signalosome assembly
Publication Title: Journal of Leukocyte Biology -
Description Immunocolocalization of PMN markers and activated neovessels in a CP. (A) Sections of the shoulder region of a CP immunostained for von Willebrand factor (vW), hemoglobin, CD66b (PMN marker), CD68...
Article Title: Involvement of intraplaque hemorrhage in atherothrombosis evolution via neutrophil protease enrichment
Publication Title: Journal of Leukocyte Biology -
Description SDF‐1α induces apoptosis of Jurkat cells. (A) Surface CXCR4 expression was determined by flow cytometry. Negative control, represented by cells treated with an isotype‐matched irrelevant mAb...
Article Title: Stromal derived factor‐1α (SDF‐1α) induces CD4+ T cell apoptosis via the functional up‐regulation of the Fas (CD95)/Fas ligand (CD95L) pathway
Publication Title: Journal of Leukocyte Biology -
Description CD8αα+CD11+ cells induce T cell death through apoptosis. (A) A representative DNA fragmentation test in pCol(28–40)‐specific T cells 3 days after incubation with CD8αα+CD11+ cells (CD8) in the...
Article Title: Identification of a bone marrow‐derived CD8αα+ dendritic cell‐like population in inflamed autoimmune target tissue with capability of inducing T cell apoptosis
Publication Title: Journal of Leukocyte Biology -
Description Histology 24 h after AKI. (A, D, G, and J) Renal morphology was assessed after PAS stain and revealed a loss of the brush‐border membrane and tubular damage mainly in the outer medulla (OM; B, E,...
Article Title: Alpha1‐antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance
Publication Title: Journal of Leukocyte Biology -
Description Unlike PMNs, SRBCs require sialidase pretreatment to accept the ST‐mediated transfer of sialyl residues. CMP‐5‐FITC‐NEU (25 μM) was added to PMNs and SRBCs, which were treated (closed bars) or not...
Article Title: Expression of sialyltransferase activity on intact human neutrophils
Publication Title: Journal of Leukocyte Biology -
Description DO11.10 +/− mice exhibit significant increases in lung cell and LALN cell numbers after OVA‐aerosol exposure. All mice received 3 weekly aerosols of saline or OVA. Numbers of total lung cells (from...
Article Title: Ovalbumin aerosols induce airway hyperreactivity in naïve DO11.10 T cell receptor transgenic mice without pulmonary eosinophilia or OVA‐specific antibody
Publication Title: Journal of Leukocyte Biology -
Description FACS sorting strategy for the purification of BM populations representing six successive stages of terminal neutrophil differentiation. (A) EPMs and LPMs, MYs, MMs, BCs, and PMNs were purified from...
Article Title: Technical Advance: Immunophenotypical characterization of human neutrophil differentiation
Publication Title: Journal of Leukocyte Biology -
Description TIP‐B1 protein expression in rat spleen. Immunohistochemical stainingusing 10μg/mL of affinity‐purified anti‐carboxy‐15‐mer antibody ofrat spleen was performed. Similar results were obtained in...
Article Title: Expression, tissue distribution, and cellular localization of the antiapoptotic TIP‐B1 protein
Publication Title: Journal of Leukocyte Biology