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Displaying assets 1 - 30 of 4980 in total. Search results limited to 100 out of 166 pages. Please refine your search query.
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Description Effect on bleeding time in the rabbit. Rabbit ear bleeding time was measured after dosing with BB‐10153 (10 mg kg−1, n = 4, black bars) and tissue‐type plasminogen activator (t‐PA) (3 mg−1, n = 4,...
Article Title: Thrombolytic activity of BB‐10153, a thrombin‐activatable plasminogen
Publication Title: Journal of Thrombosis and Haemostasis -
Description Platelet attachment to the spherical bodies. (A) Scanning electron microscopy and (B) transmission electron microscopy observation showed that platelets could adhere to the spheres (*). Scale bars:...
Article Title: Mechanisms underlying FeCl3‐induced arterial thrombosis
Publication Title: Journal of Thrombosis and Haemostasis -
Description Detection of low‐level platelet activating antibodies in EIA‐positive/SRA‐negative sera following concentration and testing in the standard SRA. Four‐fold concentration of EIA‐positive/SRA‐negative...
Article Title: Distinguishing between anti–platelet factor 4/heparin antibodies that can and cannot cause heparin‐induced thrombocytopenia
Publication Title: Journal of Thrombosis and Haemostasis -
Description p300 mediates acetylation of actin‐associated proteins. (A) Platelets (5 × 108 mL−1) pretreated with p300 inhibitors C646 (10 μm) or L002 (10 μm) prior to collagen‐related peptide (CRP)...
Article Title: Lysine acetyltransfer supports platelet function
Publication Title: Journal of Thrombosis and Haemostasis -
Description Cost‐effectiveness plane for computerized dosing compared with manual dosing.
Article Title: The cost‐effectiveness of computer‐assisted anticoagulant dosage: results from the European Action on Anticoagulation (EAA) multicentre study
Publication Title: Journal of Thrombosis and Haemostasis -
Description MCP‐1 was significantly decreased in Vn−/− and PAI‐1 Tg mice in both the vein wall (A) and thrombus at days 2 and 6 (B, n = 5–10). Vein wall monocyte influx (C) but not intrathrombus monocyte...
Article Title: Plasminogen activator‐1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non‐vitronectin‐dependent mechanism
Publication Title: Journal of Thrombosis and Haemostasis -
Description 2MeSADP and AYPGKF‐induced platelet aggregation in wild‐type and low‐density lipoprotein receptor‐deficient mice (LDLR−/−) mice on chow (c), Western (w) and Paigen (p) diets in response to a low...
Article Title: Contribution of the P2Y12 receptor‐mediated pathway to platelet hyperreactivity in hypercholesterolemia
Publication Title: Journal of Thrombosis and Haemostasis -
Description Gene expression levels of molecules involved in proplatelet formation in mature megakaryocytes incubated with anagrelide. Megakaryocytes were differentiated from cord blood CD34+ cells, then CD41+...
Article Title: Anagrelide platelet‐lowering effect is due to inhibition of both megakaryocyte maturation and proplatelet formation: insight into potential mechanisms
Publication Title: Journal of Thrombosis and Haemostasis -
Description Reverse transcription‐polymerase chain reaction (RT‐PCR) analysis for the β3 330–336 TCCCCAG deletion showing a transcript moving very closely with the normal control transcript of 863 bp,...
Article Title: Diversity of Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15 unrelated patients
Publication Title: Journal of Thrombosis and Haemostasis -
Description Procoagulant activity of C6 glioma cells. (A) C6 cells, in phosphate‐buffered saline (PBS), at the indicated concentrations were incubated with rat plasma followed by recalcification with 12.5 mm...
Article Title: On the molecular mechanisms for the highly procoagulant pattern of C6 glioma cells
Publication Title: Journal of Thrombosis and Haemostasis -
Description Anticoagulant activity of heparin (black symbols), the native (red) and low molecular weight sulfated galactans from Botryocladia occidentalis (blue) and native sulfated galactan from Acanthophora...
Article Title: Is the antithrombotic effect of sulfated galactans independent of serpin?
Publication Title: Journal of Thrombosis and Haemostasis -
Description Forest plots of (A) volume of red cells transfused and (B) risk of allogeneic red cell transfusion. Size of squares for risk ratio reflects weight of trial in pooled analysis. Horizontal bars...
Article Title: Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta‐analysis of randomized controlled trials
Publication Title: Journal of Thrombosis and Haemostasis -
Description Three‐year cumulative rates of venous thromboembolism (VTE) recurrence in patients with a first isolated superficial vein thrombosis (SVT) or a first isolated proximal deep vein thrombosis (DVT)....
Article Title: Long‐term risk of venous thromboembolism recurrence after isolated superficial vein thrombosis
Publication Title: Journal of Thrombosis and Haemostasis -
Description Complex formation between hepatocyte growth factor activator (HGFA) and protein C inhibitor (PCI). The 34‐kDa HGFA (800 nmol L−1) was incubated with PCI (980 nmol L−1) at 37 °C for the indicated...
Article Title: Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator
Publication Title: Journal of Thrombosis and Haemostasis -
Description Parasitized red blood cells (pRBC) induce TF expression and productive assembly of the extrinsic Xnase complex in microvascular endothelial cells. (A) Functional assays for tissue factor (TF). (B)...
Article Title: Plasmodium falciparum‐ infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes
Publication Title: Journal of Thrombosis and Haemostasis -
Description Spliceosome‐mediated RNA trans‐splicing (SmaRT). The therapeutic trans‐splicing is based on the substitution of the 5′ (left), internal (middle) or 3′ (right) exons (light grey rectangles). The...
Article Title: RNA‐based therapeutic approaches for coagulation factor deficiencies
Publication Title: Journal of Thrombosis and Haemostasis -
Description Involvement of protease‐activated receptor (PAR)‐1 in plasmin‐induced DNA synthesis. (A) Quiescent monolayers of wild‐type mouse fibroblasts (filled bars) or PAR‐1‐deficient mouse fibroblasts...
Article Title: A novel mechanism of plasmin‐induced mitogenesis in fibroblasts
Publication Title: Journal of Thrombosis and Haemostasis -
Description Drospirenone (DRSP)‐enhanced GPIb‐IX‐V‐mediated platelet activation was eliminated by indomethacin or apyrase. Washed human platelets were pre‐incubated with dimethylsulfoxide (DMSO) or DRSP (60 ng...
Article Title: Drospirenone enhances GPIb‐IX‐V‐mediated platelet activation
Publication Title: Journal of Thrombosis and Haemostasis -
Description L. lactis expressing staphylococcal ClfA binds to vWbp. (A) Micro‐parallel plate flow chamber perfusion over coated rvWbp (30 μg mL−1) with fluorescently labeled L. lactis pIL253, L. lactis ClfA+,...
Article Title: Clumping factor A, von Willebrand factor‐binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall
Publication Title: Journal of Thrombosis and Haemostasis -
Description Bar chart illustrating the comparisons of potencies using different predilution methods. Here the buffer prediluent potency is expressed as a percentage difference from the deficient plasma potency.
Article Title: Variability in factor VIII concentrate measurement: results from SSC field collaborative studies
Publication Title: Journal of Thrombosis and Haemostasis -
Description Splice variants of the fibrinogen γ chain mRNA. Genomic structures of the γ chain gene in wild type (WT), hu‐γ′ mice, and hu‐γ′Δneo mice are illustrated (lower right). Primer location and direction...
Article Title: Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin‐binding γ′ chain sequence
Publication Title: Journal of Thrombosis and Haemostasis -
Description Cardioprotective effect of antithrombin (AT) is mediated through the interaction with heparan sulfate proteoglycans (HSPGs) independent of its anticoagulant activity. Hearts were subjected to 20...
Article Title: Antithrombin is protective against myocardial ischemia and reperfusion injury
Publication Title: Journal of Thrombosis and Haemostasis -
Description Effect of polyclonal antibodies against leptin and leptin receptor on leptin‐stimulated MN. OB (Y‐20), a leptin antibody, or Ob‐R (H‐300), a leptin receptor antibody, were incubated with MN 30 min...
Article Title: Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk?
Publication Title: Journal of Thrombosis and Haemostasis -
Description Antibody against plasmin and streptokinase (SK). (A) Antiplasmin antibody levels at baseline and at day 28, expressed as optical density ± SD. (B) A similar analysis of antibody against SK, with...
Article Title: A first‐in‐human phase I trial of locally delivered human plasmin for hemodialysis graft occlusion
Publication Title: Journal of Thrombosis and Haemostasis -
Description Antepartum recurrent venous thromboembolism (VTE) (WMD 1.97% [95% CI 0.88–3.49%; I2 39.5%]).
Article Title: Anticoagulant therapy for venous thromboembolism during pregnancy: a systematic review and a meta‐analysis of the literature
Publication Title: Journal of Thrombosis and Haemostasis -
Description Identification of PMM2‐CDG in the proband. (A) Native and SDS‐PAGE showing the normal (arrow) and abnormal (dashed arrow) antithrombin present in plasma of the proband, a patient with congenital...
Article Title: Congenital disorder of glycosylation (PMM2‐CDG) in a patient with antithrombin deficiency and severe thrombophilia
Publication Title: Journal of Thrombosis and Haemostasis -
Description Factor H (FH) binding to platelets. (A) A dose‐dependent increase in binding of radiolabeled FH to thrombin‐activated platelets () vs. non‐activated (). The abscissa shows the total amount of FH...
Article Title: Factor H binds to washed human platelets
Publication Title: Journal of Thrombosis and Haemostasis -
Description Effect of RUNX1 small interfering RNA (siRNA) on platelet factor 4 (PF4) promoter activity and PF4 level. (A) PF4 promoter activity: human erythroleukemia (HEL) cells were cotransfected with mock...
Article Title: Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
Publication Title: Journal of Thrombosis and Haemostasis -
Description FX activation by FIXa mutants in the absence and presence of FVIIIa. FX was incubated in 25 mM HEPES (pH 7.35), 175 mM NaCl, 5 mM CaCl2, 1 mg mL−1 HSA with 10 μM phospholipids and (A) 6 nM FIXa in...
Article Title: Factor IX mutants with enhanced catalytic activity
Publication Title: Journal of Thrombosis and Haemostasis -
Description Identification and bioinformatic analysis of the F5 IVS8 +268A→G mutation. Top left: amplification from genomic DNA of a 295‐bp fragment spanning the pseudo‐exon in F5 intron 8 (primers are...
Article Title: Homozygous F5 deep‐intronic splicing mutation resulting in severe factor V deficiency and undetectable thrombin generation in platelet‐rich plasma
Publication Title: Journal of Thrombosis and Haemostasis
Displaying assets 1 - 30 of 4980 in total. Search results limited to 100 out of 166 pages. Please refine your search query.