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Displaying assets 1 - 30 of 395 in total.
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Description Expression of active caspase-3 in the left ventricles (LVs) of all groups of rats as detected by immunohistochemistry. a, b Taken from control and control + AG-treated rats, respectively, and show...
Article Title: Acylated ghrelin prevents doxorubicin-induced cardiac intrinsic cell death and fibrosis in rats by restoring IL-6/JAK2/STAT3 signaling pathway and inhibition of STAT1
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Model for β2-AR- and prostanoid-receptor-mediated phospholipase C and calcium signaling as proposed in 2001. Upper panel: Scheme adapted from (Schmidt et al. 2001). Receptors coupling to Gs...
Article Title: cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology—tribute to Karl H. Jakobs
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description The release of lactate dehydrogenase with different concentrations (1, 10, 50, and 100 μM) of GML and GML nanocapsules (NGML). Cells were considered as negative control (Neg) and H2O2 as positive...
Article Title: Glycerol monolaurate nanocapsules for biomedical applications: in vitro toxicological studies
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Hematoxylin and eosin (H&E) staining of cortex (magnification, × 400). The presence of vacuolation, deformed, and shrunk nuclei in ischemia group is more than sham, positive control, and treated group
Article Title: Neuroprotective effect of chlorogenic acid in global cerebral ischemia-reperfusion rat model
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Synthesis of 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol (LQFM032). HCl, hydrochloric acid; MeOH, methanol; Rx Duff, Duff condition; HTMA, hexamethylenetetramine; CF3CO2H,...
Article Title: Novel choline analog 2-(4-((1-phenyl-1-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of ambroxol on 6-OHDA-induced alterations in GCase enzymatic activity (a) and α-synuclein protein concentration (b) in ipsilateral nigral tissues of rats. All values are mean ± SD; n = 6; ap...
Article Title: Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson’s disease
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Signaling by sphingosine-1-phosphate (S1P). S1P is generated from sphingosine by SphKs. There are two SphK isoforms which have several splice variants. SphKs are regulated transcriptionally and...
Article Title: cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology—tribute to Karl H. Jakobs
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of arsenic trioxide (3.5 mg/kg/day, orally), curcumin (200 mg/kg/day, orally), and their combination on a fibrosis score, b tubular injury, and cα-SMA expression score. Values are expressed...
Article Title: Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Parameter estimates of the plasma pharmacokinetic model of telavancin and bootstrap (1000 samples) estimates with 90% confidence intervals (CI)
Article Title: A population pharmacokinetic model of intravenous telavancin in healthy individuals to assess tissue exposure
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description The effects of an H3 receptor inverse agonist (ciproxifan) on H4 receptor antagonist-induced improvement of anorexia in mice. Ciproxifan (0.5 or 1 mg/kg) and JNJ7777120 (10 mg/kg) were...
Article Title: Activation of orexinergic and histaminergic pathway involved in therapeutic effect of histamine H receptor antagonist against cisplatin-induced anorexia in mice
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effects of pinacidil on nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) in isolated cardiac ventricular myocytes. a The effect of pinacidil on NO production was measured by summing NO2−...
Article Title: Pinacidil, a KATP channel opener, stimulates cardiac Na/Ca exchanger function through the NO/cGMP/PKG signaling pathway in guinea pig cardiac ventricular myocytes
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Ambroxol-induced recovery of motor functions as assessed by apomorphine-induced rotations (a), latency in cataleptic behavior (b), rotarod retention time (c), and grip strength score (d) against...
Article Title: Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson’s disease
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of BBAPH-1 on HRV changes in MNU-induced mammary gland carcinogenesis
Article Title: PHD-2 activation: a novel strategy to control HIF-1α and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Intra-day and inter-day values of accuracies and recoveries of naproxen in rat plasma
Article Title: Pharmacokinetics and anti-inflammatory effect of naproxen in rats with acute and subacute spinal cord injury
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Bcl-2 expression in the rat kidney tissue. a Control group; negative Bcl-2 expression. b CYP group; mild Bcl-2 expression in the cytoplasm of tubular epithelium. c CH 50 group; negative Bcl-2...
Article Title: Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of treatment with tocilizumab (TOC) on urine albumin/creatinine ratio (UACR, mg/mmol) in streptozotocin (STZ, 65 mg/kg)-treated rats
Article Title: Effect of tocilizumab, an interleukin-6 inhibitor, on early stage streptozotocin-induced diabetic nephropathy in rats
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of S. capsicoides fractions administration on behavioral parameters in the open field test in mice
Article Title: Antidepressant-like effect and toxicological parameters of extract and withanolides isolated from aerial parts of All. (Solanaceae)
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of treatment with compound-1 (10 mg/kg) on inhibition of CFA-induced a acute mechanical hyperalgesia, b chronic mechanical hyperalgesia, c acute mechanical allodynia, d chronic mechanical...
Article Title: A new cationic palladium(II) dithiocarbamate exhibits anti-inflammatory, analgesic, and antipyretic activities through inhibition of inflammatory mediators in in vivo models
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Drug effect on complex II-linked mitochondrial respiration in isolated pig brain mitochondria. Dose-response curves are displayed as plots of the relative respiratory rate against the drug...
Article Title: In vitro effects of antipsychotics on mitochondrial respiration
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of resveratrol on ovarian caspase-3 expression in cisplatin-induced ovarian injury in rats. a Immunohistochemical localization of ovarian caspase-3. Control and resveratrol groups showed...
Article Title: Mechanistic perspective of protective effects of resveratrol against cisplatin-induced ovarian injury in rats: emphasis on anti-inflammatory and anti-apoptotic effects
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effects of arsenic trioxide, curcumin treatment, and their combination on tubular injury induced by cisplatin. The Cis group showed marked increased number of α-SMA positive cells compared to...
Article Title: Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description a Effect of dieckol on the levels of TBARS in normal and γ-radiation-induced hepatocytes cells. ∧Significantly different from control p < 0.05. *Significantly different from γ-radiation p < 0.05....
Article Title: Radioprotective efficacy of dieckol against gamma radiation-induced cellular damage in hepatocyte cells
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Cardiovascular and sympathetic responses evoked by atropine and L-NAME pretreatments on LQFM032 effects in spontaneously hypertensive rats (SHRs). Effects of intravenous pretreatment with atropine...
Article Title: Novel choline analog 2-(4-((1-phenyl-1-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Bromelain improved the physiological function of the sciatic nerve. Bromelain progressively improved the sciatic function index of the ligated hind limb. Values are expressed in mean ± SEM, n = 8....
Article Title: Bromelain reversed electrolyte imbalance in the chronically constricted sciatic nerve of Wistar rats
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Andrographolide blocks astrocytic activation and promotes BDNF-TrkB signaling in the hippocampus. a Immunofluorescent staining of GFAP (green) and BDNF (red) in the hippocampal CA1 region. b...
Article Title: Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of phenoxodiol on reactive oxygen species. a Histogram of DCFDA fluorescence in erythrocytes following exposure for 48 h to Ringer solution without (gray area) and with (black line) presence...
Article Title: Triggering of eryptosis, the suicidal erythrocyte death, by phenoxodiol
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Effect of RA on Galβ1-4GlcNAc; GlcNAc (detected by DSA lectin) (a) and GalNAcβ1-4GlcNAc (detected by WFA lectin) (b) sugar antigens expression in skin fibroblasts assayed by ELISA test in cell...
Article Title: Glycosylation of proteins of human skin fibroblasts is changed by rosmarinic acid
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description TAE and AA restore cellular antioxidant status. Data represented as mean ± SEM of three independent experiments. Different signs indicate statistically significant differences,*p < 0.05 versus...
Article Title: extract and arjunic acid mitigate cobalt chloride–induced hypoxia stress–mediated apoptosis in H9c2 cells
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Three dimensional structure of CYP2D6 (PDB: 3TBG) rendered as ribbon diagram showing locations of amino acid variants. Helices are designated by letters, and the β sheets are numbered. The heme...
Article Title: Functional and structural characterisation of common cytochrome P450 2D6 allelic variants—roles of Pro34 and Thr107 in catalysis and inhibition
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology -
Description Ambroxol-induced recovery of motor functions as assessed by the number of central squares crossed (a), ambulation (b), grooming (c), and rearing (d) in open field test against 6-OHDA-induced motor...
Article Title: Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson’s disease
Publication Title: Naunyn-Schmiedeberg's Archives of Pharmacology
Displaying assets 1 - 30 of 395 in total.