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Displaying assets 1 - 30 of 157 in total.
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Description Donor P2X7 activity correlates with P2RX7 genotype on human monocyte subsets and NK cell subsets. a–i hPBMCs, from donors of either GOF or LOF P2RX7 genotype, in NaCl medium were incubated with 1...
Article Title: Altered donor P2X7 activity in human leukocytes correlates with genotype but does not affect the development of graft-versus-host disease in humanised mice
Publication Title: Purinergic Signalling -
Description Application of a low K+ solution induced calcium-dependent ATP release from DH glial cells. a In fura-2-loaded DH glial cells, local application of an extracellular solution in which the...
Article Title: High-resolution detection of ATP release from single cultured mouse dorsal horn spinal cord glial cells and its modulation by noradrenaline
Publication Title: Purinergic Signalling -
Description The effect of Bz-ATP, α,β-meATP and β,γ-meATP on TNAP activity and ATP release and breakdown. a Bz-ATP, b α,β-meATP and c β,γ-meATP (≥ 10 μM) increased VSMC TNAP activity by up to 5.9-fold. d Basal...
Article Title: Inhibition of vascular smooth muscle cell calcification by ATP analogues
Publication Title: Purinergic Signalling -
Description Mechanisms of ATP secretion. a Yac-1 cells were incubated in ECS/1 mM CaCl2 containing different concentrations of the pannexin-1 inhibitor carbenoxolone (CBX) and incubated for 30 min with or...
Article Title: P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP
Publication Title: Purinergic Signalling -
Description CD39 deficiency worsens liver fibrosis in the DDC-induced model of biliary fibrosis. a Representative images of Sirius Red stained liver sections from WT and CD39 KO mice after 3 weeks of DDC...
Article Title: Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis
Publication Title: Purinergic Signalling -
Description Bile acids inhibit rat P2X2 at micromolar concentrations. a Representative current traces of Xenopus laevis oocytes expressing rat P2X2; P2X2 was activated by ATP (10 μM, black bar). Blue bars...
Article Title: Bile acids are potent inhibitors of rat P2X2 receptors
Publication Title: Purinergic Signalling -
Description Donor P2X7 activity correlates with P2RX7 genotype on human T cell subsets. a-k hPBMCs, from donors of either GOF or LOF P2RX7 genotype, resuspended in NaCl medium were incubated with 1 μM...
Article Title: Altered donor P2X7 activity in human leukocytes correlates with genotype but does not affect the development of graft-versus-host disease in humanised mice
Publication Title: Purinergic Signalling -
Description Participants of the “1st Sino-German Symposium on Purinergic Signalling, Pain and Acupuncture” (Chengdu, October 10–15, 2012). First row middle from left to right: Yong Tang, Peter Illes, Geoffrey...
Article Title: From the Sino-German collaboration on purines to the Chinese Purine Club
Publication Title: Purinergic Signalling -
Description Development of the ABR threshold shifts during noise exposure. P2rx2(+/+) mice (wildtype, WT; blue fill) exhibited approximately half the purinergic hearing adaptation within the first 5 min of...
Article Title: Onset kinetics of noise-induced purinergic adaptation of the ‘cochlear amplifier’
Publication Title: Purinergic Signalling -
Description Concentration-inhibition curve of 10 at human NPP1 vs. 100 μM p-Nph-5′-TMP as a substrate (Ki = 16.3 ± 2.5 μM) and Lineweaver-Burk plot of NPP1 inhibition by 10. S, substrate concentration of...
Article Title: Identification of adenine-9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes
Publication Title: Purinergic Signalling -
Description Selective adenosine receptor subtype agonists and antagonists implemented in this study. The Ki values come from the Nomenclature and Classification of Adenosine receptors—an update (Fredholm et...
Article Title: Multiple adenosine receptor subtypes stimulate wound healing in human EA.hy926 endothelial cells
Publication Title: Purinergic Signalling -
Description The effect of Bz-ATP, α,β-meATP and β,γ-meATP on calcification-induced changes in protein expression. Western blot analysis showed that calcification was associated with reduced protein levels of...
Article Title: Inhibition of vascular smooth muscle cell calcification by ATP analogues
Publication Title: Purinergic Signalling -
Description Characterisation of the effect of unlabelled ligands on the binding of XAC-S-ser-S-tyr-X-BY630 to Nluc-A3AR using NanoBRET. a Nluc-A3AR cells were treated with 40 nM XAC-S-ser-S-tyr-X-BY630 and...
Article Title: A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A receptor
Publication Title: Purinergic Signalling -
Description ATP release in response to osmotic stress. a Yac-1 cells were pre-incubated in the presence or absence of 13A7 and subjected to different degrees of osmotic stress by diluting ECS with water as...
Article Title: P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP
Publication Title: Purinergic Signalling -
Description Time course of the effect of EA on the behaviour of TNBS-induced mice. a Effect of EA on the mechanical withdrawal threshold of TNBS-induced mice. b Effect of EA on body weight (body weight divided...
Article Title: Electroacupuncture inhibits visceral pain via adenosine receptors in mice with inflammatory bowel disease
Publication Title: Purinergic Signalling -
Description Modelling of kinetics of purinergic adaptation from ABR threshold shifts during noise exposure. Best fit single exponential fit to the growth of the ABR threshold shift with cumulative broadband...
Article Title: Onset kinetics of noise-induced purinergic adaptation of the ‘cochlear amplifier’
Publication Title: Purinergic Signalling -
Description Immunolocalization of NTPDase2 in a human uterus with adenomyosis. Image A shows the immunolabeling of NTPDase2 at the stroma of the basal layer of the endometrium and at the stroma of adenomyosis...
Article Title: The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells
Publication Title: Purinergic Signalling -
Description Previously reported NPP1 inhibitors
Article Title: Identification of adenine-9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes
Publication Title: Purinergic Signalling -
Description A1 and A2B receptors are expressed on Müller cells. The cell bodies, processes (arrowheads), and endfeet (arrows) of Müller cells express a A1R and b A2BR. Additionally, A2BR is strongly expressed...
Article Title: Adenosine receptor expression in the adult zebrafish retina
Publication Title: Purinergic Signalling -
Description Functional characterization of NF272
Article Title: Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y receptor antagonist
Publication Title: Purinergic Signalling -
Description Static contraction did not increase muscle levels of TNF-α and IL-1β. a A-317491 was administered (intramuscular) 5 min before static contraction was performed. The muscle was collected ½, 1, 3, 6,...
Article Title: P2X3 receptors contribute to muscle pain induced by static contraction by a mechanism dependent on neutrophil migration
Publication Title: Purinergic Signalling -
Description Breakdown products of α,β-meATP and β,γ-meATP also inhibit VSMC calcification. a α,β-meADP (≥ 10 μM) and b methylene diphosphonate (≥ 10 μM) inhibit VSMC calcification by up to 95% and 80%,...
Article Title: Inhibition of vascular smooth muscle cell calcification by ATP analogues
Publication Title: Purinergic Signalling -
Description The effect of the P2X1 receptor inhibition NF279 (40 mg kg−1 h−1) which do not affect bacterial growth in vitro in E. coli-induced sepsis. a Kaplan-Meier plot shows survival over 6 h after...
Article Title: P2X receptor blockers reduce the number of circulating thrombocytes and the overall survival of urosepsis with haemolysin-producing
Publication Title: Purinergic Signalling -
Description Gating of P2X7 induces secretion of ATP within minutes. Yac-1 cells pre-treated or not for 30 min with the P2X7-inhibitory nanobody 13A7 were subjected to 20 μM NAD+ for 45 min or left untreated....
Article Title: P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP
Publication Title: Purinergic Signalling -
Description Ampullary carcinoma expressing P2X7 and P2X4 receptors. Immunohistochemical staining of human ampullary carcinoma (AMC) tissue sections with P2X4 and P2X7. a Negative control of AMC tissue sample...
Article Title: Role of purinergic receptors in hepatobiliary carcinoma in Pakistani population: an approach towards proinflammatory role of P2X4 and P2X7 receptors
Publication Title: Purinergic Signalling -
Description P2X1 receptor inhibition (NF279; 40 mg kg−1 h−1) in E. coli-induced sepsis. Anaesthetised mice were injected iv with 41.3 × 106 HlyA-producing E. coli for 2.5 h during constant infusion either...
Article Title: P2X receptor blockers reduce the number of circulating thrombocytes and the overall survival of urosepsis with haemolysin-producing
Publication Title: Purinergic Signalling -
Description Characterisation of the effect of unlabelled ligands on the binding of AV039 to Nluc-A3AR using NanoBRET (a). Nluc-A3AR cells were treated with 50 nM AV039 and increasing concentrations of PSB-11...
Article Title: A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A receptor
Publication Title: Purinergic Signalling -
Description Wound healing scratch assay using different concentrations of CPA on EA.hy926 endothelial cells. Upper panel depicts scratch widths at 0 times and lower panel shows scratch widths after 6 h. CPA...
Article Title: Multiple adenosine receptor subtypes stimulate wound healing in human EA.hy926 endothelial cells
Publication Title: Purinergic Signalling -
Description Adenine nucleotide analogs synthesized and evaluated here as NPP1 inhibitors
Article Title: Identification of adenine-9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes
Publication Title: Purinergic Signalling -
Description Cubic (2f1–f2) DPOAE input/output functions assessed for P2rx2(+/+) mice (wildtype, WT) and P2rx2(−/−) mice (knockout, KO) with exposure to moderate noise (85 dB SPL, 9–32 kHz). a Examples of fast...
Article Title: Onset kinetics of noise-induced purinergic adaptation of the ‘cochlear amplifier’
Publication Title: Purinergic Signalling
Displaying assets 1 - 30 of 157 in total.