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Displaying assets 1 - 30 of 60895 in total. Search results limited to 100 out of 2030 pages. Please refine your search query.
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Description Binding schematic of the complex interface. Total buried surface area per residue is shown under the residue ID. Sequence comparison with the BMP and TGF‐β subfamilies are shown to the right and...
Article Title: Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF‐β ligand:receptor interactions
Publication Title: The EMBO Journal -
Description NMR structure of the DDR2‐DS domain. (A) Twenty backbone models of the DDR2‐DS domain (residues 26–186) were superimposed. The β‐strand regions are colored blue and the other regions are pink. The...
Article Title: Structural basis of the collagen‐binding mode of discoidin domain receptor 2
Publication Title: The EMBO Journal -
Description dsRNA synthesis on three luciferase ssRNAs extended with 9 nt sequence from the 3′ termini of the different φ6 segments. (A) Reaction mixtures containing 70 μg/ml (120 nM) ssRNA templates...
Article Title: The polymerase subunit of a dsRNA virus plays a central role in the regulation of viral RNA metabolism
Publication Title: The EMBO Journal -
Description (A) A Bobscript (Esnouf, 1997) and RASTER3D (Merritt and Murphy, 1994) stereo depiction of the 1.9 Å (Fobs − Fcalc, αaveraged) omit electron density map. Calculated structure factor amplitudes were...
Article Title: The structure and function of a foot‐and‐mouth disease virus–oligosaccharide receptor complex
Publication Title: The EMBO Journal -
Description Yeast strains and plasmids used in this study
Article Title: Interaction of the yeast γ‐tubulin complex‐binding protein Spc72p with Kar1p is essential for microtubule function during karyogamy
Publication Title: The EMBO Journal -
Description Overexpression of MOF1 in S2 cells causes a reduction in the level of H4Ac16 present on the X chromosomes and relocation of MSL complexes. Histone H4Ac16 in S2 cells transfected with the vector (A)...
Article Title: Targeting the chromatin‐remodeling MSL complex of Drosophila to its sites of action on the X chromosome requires both acetyl transferase and ATPase activities
Publication Title: The EMBO Journal -
Description β2‐Chimaerin inhibits EGF‐induced activation of Rac1 and Rac‐mediated responses. (A) HeLa cells were infected with a recombinant HA‐β2‐chim‐AdV or a LacZ‐AdV (MOI 10 PFU/cell, 16 h). Cells were...
Article Title: Phospholipase Cγ/diacylglycerol‐dependent activation of β2‐chimaerin restricts EGF‐induced Rac signaling
Publication Title: The EMBO Journal -
Description Structure of AfAlkA. β‐Strands are shown in blue and α‐helices in red (except for the two α‐helices forming the HhH motif, αK–αL, which are shown in green). (A) Stereo representation of the overall...
Article Title: Structural basis for enzymatic excision of N1‐methyladenine and N3‐methylcytosine from DNA
Publication Title: The EMBO Journal -
Description Restoration of 2′‐O‐methylation of the W‐U5 RNA. (A) Schematic structure of the pCMV‐globin‐yU24m expression construct and expression of the yU24m snoRNA. The promoters of the cytomegalovirus (CMV)...
Article Title: Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm
Publication Title: The EMBO Journal -
Description CDC6 is phosphorylated in vivo on CDK phosphorylation sites, and the phosphorylation state of CDC6 does not affect the kinase interaction. (A) U2OS cells transfected with empty vector (Mock),...
Article Title: Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization
Publication Title: The EMBO Journal -
- Identifier
- embj2013212-fig-0002
- License Type
- CC-BY
- Rights Holder
- Rights Managed by John Wiley & Sons
Description Endophilin colocalizes with the C‐terminus of Lamellipodin at induced membrane tubules. (A) Full‐length (FL) and truncation mutants of Lpd with their respective protein tags used in this study are...
Article Title: Endophilin, Lamellipodin, and Mena cooperate to regulate F‐actin‐dependent EGF‐receptor endocytosis
Publication Title: The EMBO Journal -
Description A model of early developmental stages of T cell development in the human thymus.
Article Title: Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors
Publication Title: The EMBO Journal -
Description Blockade of NAADP receptors by a high desensitizing concentration of NAADP abolishes Ca2+ spiking in response to CCK, but not to ACh stimulation. A low, physiological, CCK concentration (2 pM)...
Article Title: Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP‐ribose and inositol trisphosphate
Publication Title: The EMBO Journal -
Description Lys‐CoA inhibits myotube formation. C2C12 cells were permeabilized in the presence or absence of Lys‐CoA, and placed in differentiation medium; after 3 days, cells were fixed and labeled with...
Article Title: CBP/p300 and muscle differentiation: no HAT, no muscle
Publication Title: The EMBO Journal -
Description AB6 mice were orally gavaged with 109 CFU NCK56 or NCK2187, and the colonic gene expression of C‐type lectin receptors were measured by RT–PCR. Each box represents an individual mouse; n = 4. Data...
Article Title: SIGNR3‐dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis
Publication Title: The EMBO Journal -
Description SIR2 and UTH4 are necessary for the localization of Sir3p to the nucleolus in a sir4::HIS3 strain. In (a–d), the haploid strains UCC3107 (SIR+, a), UCC3203 (sir2::HIS3, b), UCC3207 (sir4::HIS3, c)...
Article Title: Localization of Sir2p: the nucleolus as a compartment for silent information regulators
Publication Title: The EMBO Journal -
Description YaeL PDZ region and complementation abilities of mutant forms of YaeL. (A) The amino acid sequence of the YaeL PDZ homologous region and the mutational alterations constructed in this study. The...
Article Title: YaeL proteolysis of RseA is controlled by the PDZ domain of YaeL and a Gln‐rich region of RseA
Publication Title: The EMBO Journal -
Description Replication of STC proceeds by semi‐discontinuous DNA synthesis. (A) BamHI and NdeI cleave asymmetrically in the donor vector but not within the mini‐Mu element or the transposition target....
Article Title: The φX174‐type primosome promotes replisome assembly at the site of recombination in bacteriophage Mu transposition
Publication Title: The EMBO Journal -
Description Cooperative stimulation of E2F‐1/DP‐1 transcriptional activity by KRIP‐1 and the TRIP‐Br proteins. (A) SAOS2 cells were transiently transfected with the indicated expression constructs, 3 μg of the...
Article Title: TRIP‐Br: a novel family of PHD zinc finger‐ and bromodomain‐interacting proteins that regulate the transcriptional activity of E2F‐1/DP‐1
Publication Title: The EMBO Journal -
Description Model of proteolytic processing of OPA1. See Discussion for details.
Article Title: Regulation of mitochondrial morphology through proteolytic cleavage of OPA1
Publication Title: The EMBO Journal -
Description Proposed mechanism of the intramolecular aldol condensation catalysed by SnoaL. The first step of the reaction is the generation of the carbanion/enol(ate) intermediate by abstraction of a proton...
Article Title: Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation
Publication Title: The EMBO Journal -
Description Mutation of ubiquitin acceptor sites in Malt1 abrogates NF‐κB activation and IL‐2 production in primary T cells. Malt1−/− CD4‐positive T cells were infected with retroviral constructs coupling...
Article Title: Malt1 ubiquitination triggers NF‐κB signaling upon T‐cell activation
Publication Title: The EMBO Journal -
Description SDS–PAGE analysis of purified mycoAC204–443 mutant constructs (Coomassie blue staining). Molecular mass standards are on the left. The following amounts of protein were applied (left to right):...
Article Title: Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases
Publication Title: The EMBO Journal -
- Identifier
- embj201796636-fig-0005
- License Type
- CC-BY
- Rights Holder
- Rights Managed by John Wiley & Sons
Description A, BOverlayed chromatograms showing absorbance at 280 nm from SEC of Ctf19‐Mcm21‐Okp1 variants without Okp1 segment 3 (A) or with Okp1 segment 3 (B); Ctf19‐Mcm21‐Okp1 variant: CMO, Nkp1‐Nkp2: NN,...
Article Title: Molecular basis for inner kinetochore configuration through RWD domain–peptide interactions
Publication Title: The EMBO Journal -
Description Cross‐linking of digitonin‐solubilized, purified His‐P2X1 and His‐P2X3. Oocytes injected with the indicated cRNAs were labeled overnight with [35S]methionine and chased for 5–10 h. Digitonin...
Article Title: P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand‐gated ion channels
Publication Title: The EMBO Journal -
Description Tdag51‐null cells are resistant to stresses. (A) Western blot analysis of expression of Tdag51 and major Hsps using extracts isolated from untreated (C) wild‐type (Tdag+/+) and Tdag51‐null MEF...
Article Title: A novel HSF1‐mediated death pathway that is suppressed by heat shock proteins
Publication Title: The EMBO Journal -
Description Role of EGFR ligands in TNFR1 shedding. (A) 1HAEo− cells were incubated with protein A or media alone (U: unstimulated) and TGF‐α was detected in culture supernatants by ELISA. Data represent the...
Article Title: Staphylococcus aureus protein A activates TACE through EGFR‐dependent signaling
Publication Title: The EMBO Journal -
Description RA increases the amount of RARγ2 phosphorylated in its AF‐1 domain, subsequent to the activation of p38MAPK. (A) COS‐1 cells plated in 10 cm Petri dishes and cotransfected with the DR5‐tk‐CAT...
Article Title: Phosphorylation by p38MAPK and recruitment of SUG‐1 are required for RA‐induced RARγ degradation and transactivation
Publication Title: The EMBO Journal -
Description FAT1 binds to and recruits Ena/VASP proteins. (A) HA‐tagged FAT1 cytoplasmic domain expressed in COS 7 cells was pulled down using bacterially expressed recombinant GST‐VASP‐EVH1 domain (anti‐HA...
Article Title: Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization
Publication Title: The EMBO Journal -
Description Hsp15 associates with the free 50S subunit of ribosomes. Polysome profile of wild‐type cells that were treated with 100 μg/ml chloramphenicol. A total of 17.5 A260 units of the lysate were loaded...
Article Title: Hsp15: a ribosome‐associated heat shock protein
Publication Title: The EMBO Journal
Displaying assets 1 - 30 of 60895 in total. Search results limited to 100 out of 2030 pages. Please refine your search query.