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Displaying assets 1 - 30 of 60908 in total. Search results limited to 100 out of 2031 pages. Please refine your search query.
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Description Three‐dimensional structure of the UvrA‐interacting domain (domain 2) of UvrB. The ribbon diagram shows the secondary structure elements and mutated residues on the proposed UvrA interacting face....
Article Title: Interactions between UvrA and UvrB: the role of UvrB's domain 2 in nucleotide excision repair
Publication Title: The EMBO Journal -
Description ABTS‐1 is a sodium‐driven chloride–bicarbonate exchanger. (A–C) Electrophysiology data from pH microelectrodes in Xenopus oocytes. In the presence of 1.5% CO2/10 mM HCO3− (pH 7.5), both ABTS‐1 (A)...
Article Title: Two types of chloride transporters are required for GABAA receptor‐mediated inhibition in C. elegans
Publication Title: The EMBO Journal -
Description The glutamate auxotrophy of an rtg2Δ mutation is rescued by the lst8‐5 but not the lst8‐1 mutation. Wild‐type PSY142 cells, and rtg2Δ, lst8‐5, rtg2Δ lst8‐5, rtg2Δ rtb2‐5 rtg3Δ, lst8‐1 and rtg2Δ...
Article Title: RTG‐dependent mitochondria to nucleus signaling is negatively regulated by the seven WD‐repeat protein Lst8p
Publication Title: The EMBO Journal -
Description Interaction of the NYAPs with the WAVE complex. (A) Proteomic analysis of NYAP2‐interacting proteins. P1 mouse brain lysate was incubated with NYAP2‐conjugated sepharose in the presence (lane 2, as...
Article Title: NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons
Publication Title: The EMBO Journal -
Description Variability analysis of the ∼35–40S RNA editing complex. (A) 3D‐MSA of individual aligned 3D RCT volumes indicated six subtypes of particle populations within the ∼35–40S sample. Landmarks are...
Article Title: Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo
Publication Title: The EMBO Journal -
Description Lcd1p shows sequence homology to several checkpoint proteins and disruption of LCD1 results in lethality that can be rescued by RNR3 overexpression. (A) Schematic representation of regions of...
Article Title: LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
Publication Title: The EMBO Journal -
Description Ca2+‐induced conformational change of the extracellular connexon surface. (A) Same connexon surface as imaged in Figure 3, but in the presence of 0.5 mM CaCl2. As visible in the raw data,...
Article Title: Conformational changes in surface structures of isolated connexin 26 gap junctions
Publication Title: The EMBO Journal -
Description The continuous DNA synthesis in cdc16‐123 mutant cells is not dependent on Cdc6p. Wild‐type cdc6::hisG GAL‐CDC6 (K6428), cdc16‐123 CDC6 (K5600) and cdc16‐123 cdc6::hisG GAL‐CDC6 (K6433) strains...
Article Title: Is the yeast Anaphase Promoting Complex needed to prevent re‐replication during G2 and M phases?
Publication Title: The EMBO Journal -
Description Comparisons of salt bridges at the γ‐phosphate‐sensing region. (A) Stereo view of the superposition of NcKin (dark colour) and RnKin (pale colour). In NcKin, there are three inter‐switch salt...
Article Title: Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules
Publication Title: The EMBO Journal -
Description Data collection and refinement statistics
Article Title: Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates
Publication Title: The EMBO Journal -
Description Expression of MEK5 and ERK5 in wild‐type and MEK5DD transgenic mice. Lysates were prepared from wild‐type (WT) and transgenic (TG) hearts, and 20 μg of protein were separated by SDS–PAGE. (A)...
Article Title: Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy
Publication Title: The EMBO Journal -
Description Schematic diagrams of collagen VI dimers and the sequence Fourier transforms from the overlap region. (A) Two 105‐nm‐long molecules assemble antiparallel with a 75 nm overlap and are linked by...
Article Title: A new twist in the collagen story—the type VI segmented supercoil
Publication Title: The EMBO Journal -
Description ATAB2 is not stably associated with polysomes and binds A/U‐rich RNAs in vitro. (A) ATAB2 does not copurify with polysomal fractions. After centrifugation on a discontinuous sucrose gradient,...
Article Title: ATAB2 is a novel factor in the signalling pathway of light‐controlled synthesis of photosystem proteins
Publication Title: The EMBO Journal -
Description Hypoxia inhibits the activity of CARE‐binding miRNAs. (A) Hypoxia overcomes miRNA‐mediated inhibition of VEGFA expression. U937 cells were incubated with miRNAs under normoxic (21% pO2, N) or...
Article Title: Repression of VEGFA by CA‐rich element‐binding microRNAs is modulated by hnRNP L
Publication Title: The EMBO Journal -
Description Overexpression of OSH7CC causes an MVB sorting defect. WT cells (Y10000) expressing Osh7CC/Osh7p from pESCOSH7CC/pESCOSH7 were grown in glucose medium to mid‐log phase and transferred to...
Article Title: AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism
Publication Title: The EMBO Journal -
Description Disruption of the tri‐snRNP in vivo by selective depletion of either the U4/U6 protein hPrp31 or the U5 protein hPrp6. (A) Anti‐Sm and anti‐40K antibodies (denoted α‐Sm, α‐40 K, etc.) were used to...
Article Title: RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di‐snRNPs in Cajal bodies
Publication Title: The EMBO Journal -
Description The FLP recombinase assay. (A) The details of the FLP recombination catalytic reaction are illustrated. FLP recombination (FLP assembly) involves association of a pair of FLP monomers (yellow...
Article Title: Differences in insulator properties revealed by enhancer blocking assays on episomes
Publication Title: The EMBO Journal -
Description Formation of specific structures of BPDE‐DNA substrates (Table I) used in this study. (A) Gel mobility shift of the flap substrates F0–F12. The substrates migrate differently on an 8%...
Article Title: Strand opening by the UvrA2B complex allows dynamic recognition of DNA damage
Publication Title: The EMBO Journal -
Description A simple model for the action of GSK3 on kinesin function. KLCs on many MBOs are pre‐phosphorylated. When GSK3 is activated by action of one or more phosphatases, it phosphorylates KLCs further....
Article Title: Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin‐based motility
Publication Title: The EMBO Journal -
Description Ectopic expression of WAVE. Myc‐tagged WAVE was expressed transiently in COS 7 cells, and the cells were stained with anti‐myc antibody (polyclonal) and phalloidin. Bar, 10 μm.
Article Title: WAVE, a novel WASP‐family protein involved in actin reorganization induced by Rac
Publication Title: The EMBO Journal -
Description Schematic representation of Tcf splice variants and their most conserved domains. Short forms of Tcf1 and Lef1 lack the N‐terminal domain, which interacts with β‐catenin. The CAD domain in Lef1 is...
Article Title: T‐cell factors: turn‐ons and turn‐offs
Publication Title: The EMBO Journal -
Description DNase I protection footprint of NhaR. A DNA fragment (242 bp) end labeled with 32P at the 3′ (bottom strand) in (A) or at the 5′ (top strand) in (B) were incubated with His‐tagged NhaR (250 and 500...
Article Title: The Na+‐specific interaction between the LysR‐type regulator, NhaR, and the nhaA gene encoding the Na+/H+ antiporter of Escherichia coli
Publication Title: The EMBO Journal -
Description The basic cluster of rmCK2α in comparison with the PSTAIRE‐helix of active CDK2. (A) RmCK2α: the basic cluster in contact with the N‐terminal segment and Lys68 as part of the active site;...
Article Title: Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 Å resolution
Publication Title: The EMBO Journal -
Description WT Parkin is more stable than pathogenic mutants. (A) Proteolytic digest of Parkin species in the presence of increasing percentage of subtilisin (w/w). The boxed area indicates the degradation of...
Article Title: Autoregulation of Parkin activity through its ubiquitin‐like domain
Publication Title: The EMBO Journal -
Description HCT and TrkB co‐localise in wild‐type motor neurons (MNs). AlexaFluor555‐conjugated HCT (red) was internalised for 1 h at 37°C; neurons were then acid‐washed, fixed and immunostained for TrkB...
Article Title: Bicaudal‐D1 regulates the intracellular sorting and signalling of neurotrophin receptors
Publication Title: The EMBO Journal -
Description Characteristics of Sm and Sm‐like proteins: phenotypes and RNA directly associated
Article Title: Sm and Sm‐like proteins assemble in two related complexes of deep evolutionary origin
Publication Title: The EMBO Journal -
Description Binding of IpaA to vinculin in a solid‐phase assay and competition experiments. (A) Vinculin displays high affinity for IpaA. Microtiter wells were coated with the GST–IpaA fusion protein at a...
Article Title: Binding of the Shigella protein IpaA to vinculin induces F‐actin depolymerization
Publication Title: The EMBO Journal -
Description Axl activation by wild‐type and mutant Gas6‐LG. Human U‐118 glioblastoma cells were incubated with 200 ng/ml Gas6‐LG proteins for 15 min, the cells lysed, and the Axl receptor immunoprecipitated....
Article Title: Structural basis for Gas6–Axl signalling
Publication Title: The EMBO Journal -
Description HMGB1 stimulates CHRAC‐ and ACF‐mediated nucleosome remodelling. (A) Nucleosomes positioned at the end of the DNA fragment (lane 1) were incubated with 5 fmol of native CHRAC and ATP, in the...
Article Title: The DNA chaperone HMGB1 facilitates ACF/CHRAC‐dependent nucleosome sliding
Publication Title: The EMBO Journal -
Description Ca2+‐induced stimulation of glutamate decarboxylation in HEK‐293T cells overexpressing aralar1 or citrin. Cultures of HEK‐293T cells expressing aralar1 (filled bars), citrin (striped bars) or empty...
Article Title: Citrin and aralar1 are Ca2+‐stimulated aspartate/glutamate transporters in mitochondria
Publication Title: The EMBO Journal
Displaying assets 1 - 30 of 60908 in total. Search results limited to 100 out of 2031 pages. Please refine your search query.