Asset Details

  • Description:
  • Modulation of GABAA receptor‐mediated inhibition by PKC in thalamic dLGN relay neurons. (A and C) RMS noise recorded from visually‐identified thalamic relay neurons within the dLGN at room temperature in the presence of 200 nm PMA (A) and 500 nm BIS‐I (C). PMA reduced the noise whereas inhibition of PKC with BIS‐I had the reverse effect. Bicuculline reveals the extent of tonic GABAA receptor activity. (B and D) Time courses for normalized data pooled from all recordings for PMA (B, n = 8) and BIS‐I (D, n = 8). (E and F) Average sIPSC waveforms for control, and after either PMA or BIS‐I. Insets: bar charts showing the lack of effect on sIPSC parameters (peak amplitude, 10–90% rise time, decay time and frequency).
  • License:
  • CC-BY
  • Rights Holder:
  • Creative Commons by John Wiley & Sons
  • License Rights Holder:
  • Copyright © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 931 x 1264
  • Image File Size:
  • 296 KB
  • Creator:
  • Damian P. Bright, Trevor G. Smart
  • Credit:
  • Bright, D. P., & Smart, T. G. (2013). Protein kinase C regulates tonic GABAA receptor‐mediated inhibition in the hippocampus and thalamus. European Journal of Neuroscience, 38(10), 3408-3423..
  • Collection:
  • Keywords:
  • Restrictions:
  • This image was published the terms of the Creative Commons Attribution (CC BY) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Permission is not required for this kind of use.
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Damian P. Bright, Trevor G. Smart
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 38
  • Publication Issue:
  • 10
  • Publication Date:
  • 11/01/2013
  • DOI:

Click on image to enlarge

Would you like to download this asset? Tell us more and we can generate a quote, license and downloadable file.

Add to Cart