• Identifier:
• cas12698-fig-0004

• Description:
• Irradiation (IR) induces phosphorylation of BRCA1‐associated protein 1 (BAP1). (a) Western blot analysis with anti‐pS592‐BAP1 antibody revealed that endogenous WT BAP1 was phosphorylated after IR at 7.5 Gy. (b) BAP1 phosphorylation levels increased in proportion to IR doses. *Non‐specific bands. (c) Immunofluorescence analysis showed dominant nuclear localization of phosphorylated‐BAP1 protein at 1 h post‐IR (7.5 Gy). (d) Western blot analysis of nuclear/cytoplasmic fractionation tested the localization of exogenously transduced BAP1 and its phosphorylated form in malignant mesothelioma cells with BAP1 deletion. HD, homozygous deletion.

• License:
• CC-BY-NC

• Rights Holder:
• Creative Commons by John Wiley & Sons

• License Rights Holder:
• © 2015 Japanese Cancer Association

• Asset Type:
• Image

• Asset Subtype:

• Image Orientation:
• Portrait

• Image Dimensions:
• x

• Image File Size:
• 386 KB

• Creator:
• Shuhei Hakiri, Hirotaka Osada, Futoshi Ishiguro, Hideki Murakami, Yuko Murakami‐Tonami, Kohei Yokoi, Yoshitaka Sekido

• Credit:
• Hakiri, S., Osada, H., Ishiguro, F., Murakami, H., Murakami‐Tonami, Y., Yokoi, K., & Sekido, Y. (2015). Functional differences between wild‐type and mutant‐type BRCA1‐associated protein 1 tumor suppressor against malignant mesothelioma cells. Cancer Science, 106(8), 990-999..

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• Restrictions:
• This image was published under the terms of the Creative Commons Attribution-NonCommercial License, (CC-BY-NC) which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. You may purchase a high resolution image file if your request is non-commercial.

• Property Release:
• No

• Model Release:
• No

• Purchasable:
• No

• Sensitive Materials:
• No

• Article Title:
• Functional differences between wild‐type and mutant‐type BRCA1‐associated protein 1 tumor suppressor against malignant mesothelioma cells

• Article Authors:
• Shuhei Hakiri, Hirotaka Osada, Futoshi Ishiguro, Hideki Murakami, Yuko Murakami‐Tonami, Kohei Yokoi, Yoshitaka Sekido

• Article Copyright Year:
• 2015

• Publication Title:
• Cancer Science

• Publication Volume:
• 106

• Publication Issue:
• 8

• Publication Date:
• 08/01/2015

• DOI: