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  • Description:
  • Model of nuclear α1‐AR signaling in adult cardiac myocytes. The figure depicts α1‐ARs localized to the inner nuclear membrane (INM; Figure ). Furthermore, α1‐ARs colocalize with Gαq, a phospholipase C isozyme (PLCβ1?), as well as PKCα, δ, and ε (Figure ) only at the nucleus. Catecholamines, such as norepinephrine (NE), are actively transported into cardiac myocytes through organic cation transporter‐3 (OCT). NE binding to α1‐ARs leads to activation of PKC in the nucleus (Figure ), and nuclear localization is required for signaling (Figure ). Signals are transported out of the nucleus through the nuclear pore complex (NPC; inhibited by lepB; Figure ). PKCδ induces phosphorylation of cTnI at the sarcomere to regulate contractility in adult cardiac myocytes (Figures and ). In addition, nuclear α1‐AR signaling induces activation of ERK in caveolae at the plasma membrane to regulate survival signaling in adult cardiac myocytes. cTnI indicates cardiac troponin I; DAG, diacylglycerol; ER/SR, endoplasmic reticulum/sarcoplasmic reticulum; ERK, extracellular signal‐regulated kinase; MEK, mitogen‐activated protein kinase kinase; NR, nucleoplasmic reticulum; PKC, protein kinase C; PTP, permeability transition pore; RYR, ryanodine receptor; α1‐ARs, α1‐adrenergic receptors.
  • License:
  • CC-BY-NC
  • Rights Holder:
  • Creative Commons by John Wiley & Sons
  • License Rights Holder:
  • Copyright © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell
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  • Image
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  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1386 x 834
  • Image File Size:
  • 450 KB
  • Creator:
  • Steven C. Wu, PhD, Erika F. Dahl, BA, Casey D. Wright, PhD, Andrew L. Cypher, BS, Chastity L. Healy, BS, Timothy D. O'Connell, PhD
  • Credit:
  • Jensen, B., O'Connell, T., Simpson, P., O'Connell, T., Jensen, B., Baker, A., Simpson, P., Cohn, J., O'Connell, T., Ishizaka, S., Nakamura, A., Swigart, P., Rodrigo, M., Simpson, G., Cotecchia, S., Rokosh, D., Grossman, W., Foster, E., Simpson, P., O'Connell, T., Swigart, P., Rodrigo, M., Ishizaka, S., Joho, S., Turnbull, L., Tecott, L., Baker, A., Foster, E., Grossman, W., Simpson, P., Huang, Y., Wright, C., Kobayashi, S., Healy, C., Elgethun, M., Cypher, A., Liang, Q., O'Connell, T., Huang, Y., Wright, C., Merkwan, C., Baye, N., Liang, Q., Simpson, P., O'Connell, T., Du, X., Fang, L., Gao, X., Kiriazis, H., Feng, X., Hotchkin, E., Finch, A., Chaulet, H., Graham, R., Du, X., Gao, X., Kiriazis, H., Moore, X., Ming, Z., Su, Y., Finch, A., Hannan, R., Dart, A., Graham, R., Dorn, G., Dorn, G., Brown, J., Boivin, B., Chevalier, D., Villeneuve, L., Rousseau, E., Allen, B., Tadevosyan, A., Maguy, A., Villeneuve, L., Babin, J., Bonnefoy, A., Allen, B., Nattel, S., Wright, C., Chen, Q., Baye, N., Huang, Y., Healy, C., Kasinathan, S., O'Connell, T., Wright, C., Wu, S., Dahl, E., Sazama, A., O'Connell, T., Tadevosyan, A., Vaniotis, G., Allen, B., Hebert, T., Nattel, S., Vaniotis, G., Del Duca, D., Trieu, P., Rohlicek, C., Hebert, T., Allen, B., O'Connell, T., Rodrigo, M., Simpson, P., DeVries, T., Neville, M., Reyland, M., O'Connell, T., Ni, Y., Lin, K., Han, H., Yan, Z., Sakurai, K., Norota, I., Tanaka, H., Kubota, I., Tomoike, H., Endo, M., McCloskey, D., Rokosh, D., O'Connell, T., Keung, E., Simpson, P., Baker, A., Andersen, G., Qvigstad, E., Schiander, I., Aass, H., Osnes, J., Skomedal, T., Solaro, R., Lin, F., Owens, W., Chen, S., Stevens, M., Kesteven, S., Arthur, J., Woodcock, E., Feneley, M., Graham, R., O‐Uchi, J., Sasaki, H., Morimoto, S., Kusakari, Y., Shinji, H., Obata, T., Hongo, K., Komukai, K., Kurihara, S., Vega, R., Harrison, B., Meadows, E., Roberts, C., Papst, P., Olson, E., McKinsey, T., Adam, S., Marr, R., Gerace, L., Jensen, B., Swigart, P., Simpson, P., Lammerding, J., Schulze, P., Takahashi, T., Kozlov, S., Sullivan, T., Kamm, R., Stewart, C., Lee, R., Brodde, O., Michel, M., Rokosh, D., Simpson, P., Filipeanu, C., Zhou, F., Fugetta, E., Wu, G., Fujita, T., Toya, Y., Iwatsubo, K., Onda, T., Kimura, K., Umemura, S., Ishikawa, Y., Lanzafame, A., Turnbull, L., Amiramahdi, F., Arthur, J., Huynh, H., Woodcock, E., Luo, D., Yang, D., Lan, X., Li, K., Li, X., Chen, J., Zhang, Y., Xiao, R., Han, Q., Cheng, H., Zhang, L., Malik, S., Pang, J., Wang, H., Park, K., Yule, D., Blaxall, B., Smrcka, A., Triposkiadis, F., Karayannis, G., Giamouzis, G., Skoularigis, J., Louridas, G., Butler, J., Skomedal, T., Borthne, K., Aass, H., Geiran, O., Osnes, J., Turnbull, L., McCloskey, D., O'Connell, T., Simpson, P., Baker, A., Endoh, M., Blinks, J., Terzic, A., Puceat, M., Clement, O., Scamps, F., Vassort, G., Solaro, R., Moir, A., Perry, S., Bodor, G., Oakeley, A., Allen, P., Crimmins, D., Ladenson, J., Anderson, P., Goldspink, P., Montgomery, D., Walker, L., Urboniene, D., McKinney, R., Geenen, D., Solaro, R., Buttrick, P., Sumandea, M., Rybin, V., Hinken, A., Wang, C., Kobayashi, T., Harleton, E., Sievert, G., Balke, C., Feinmark, S., Solaro, R., Steinberg, S., Burkart, E., Sumandea, M., Kobayashi, T., Nili, M., Martin, A., Homsher, E., Solaro, R., Bowling, N., Walsh, R., Song, G., Estridge, T., Sandusky, G., Fouts, R., Mintze, K., Pickard, T., Roden, R., Bristow, M., Sabbah, H., Mizrahi, J., Gromo, G., King, G., Vlahos, C., Braz, J., Gregory, K., Pathak, A., Zhao, W., Sahin, B., Klevitsky, R., Kimball, T., Lorenz, J., Nairn, A., Liggett, S., Bodi, I., Wang, S., Schwartz, A., Lakatta, E., DePaoli‐Roach, A., Robbins, J., Hewett, T., Bibb, J., Westfall, M., Kranias, E., Molkentin, J., Chen, L., Hahn, H., Wu, G., Chen, C., Liron, T., Schechtman, D., Cavallaro, G., Banci, L., Guo, Y., Bolli, R., Dorn, G., Mochly‐Rosen, D., Hahn, H., Yussman, M., Toyokawa, T., Marreez, Y., Barrett, T., Hilty, K., Osinska, H., Robbins, J., Dorn, G., Ladage, D., Turnbull, I., Ishikawa, K., Takewa, Y., Rapti, K., Morel, C., Karakikes, I., Hadri, L., Muller‐Ehmsen, J., Costa, K., Hajjar, R., & Kawase, Y. (2014). Nuclear Localization of α1A‐Adrenergic Receptors Is Required for Signaling in Cardiac Myocytes: An “Inside‐Out” α1‐AR Signaling Pathway. Journal of the American Heart Association, 3(2), n/a-n/a. https://doi.org/10.1161/JAHA.113.
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  • This image was published under the terms of the Creative Commons Attribution-NonCommercial License, (CC-BY-NC) which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. You may purchase a high resolution image file if your request is non-commercial.
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Steven C. Wu, PhD, Erika F. Dahl, BA, Casey D. Wright, PhD, Andrew L. Cypher, BS, Chastity L. Healy, BS, Timothy D. O'Connell, PhD
  • Article Copyright Year:
  • 2014
  • Publication Volume:
  • 3
  • Publication Issue:
  • 2
  • Publication Date:
  • 04/01/2014
  • DOI:

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