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Description (On previous page) FBXO15 and ubiquitin‐conjugating enzyme E2 R1 (Ube2r1) mediate ubiquitination of P‐glycoprotein (P‐gp), and their knockdown upregulates P‐gp expression. (a) FBXO15 expression...
Article Title: FBXO15 regulates P‐glycoprotein/ABCB1 expression through the ubiquitin–proteasome pathway in cancer cells
Publication Title: Cancer Science -
Description P‐glycoprotein (P‐gp) is degraded by the ubiquitin–proteasome pathway. (a) MG132 increases the level of ubiquitinated P‐gp. HCT‐15 and HT1080/3HisMDR cells were treated with 10 μmol/L MG132 for 4 h...
Article Title: FBXO15 regulates P‐glycoprotein/ABCB1 expression through the ubiquitin–proteasome pathway in cancer cells
Publication Title: Cancer Science -
Description Ubiquitin‐conjugating enzyme E2 R1 (Ube2r1) associates with P‐glycoprotein (P‐gp). (a) Ube2e2, Ube2g2, Ube2j1, Ube2j2, and Ube2r1 bind to FBXO15. HEK293 cells were cotransfected with the indicated...
Article Title: FBXO15 regulates P‐glycoprotein/ABCB1 expression through the ubiquitin–proteasome pathway in cancer cells
Publication Title: Cancer Science -
Description FBXO15 knockdown enhances the efflux activity of P‐glycoprotein (P‐gp). (a) FBXO15 knockdown lowers sensitivity to vincristine (VCR). HCT‐15, SW620‐14, and HT1080/3HisMDR cells were transfected...
Article Title: FBXO15 regulates P‐glycoprotein/ABCB1 expression through the ubiquitin–proteasome pathway in cancer cells
Publication Title: Cancer Science -
Description Inhibition of the proteasome upregulates P‐glycoprotein (P‐gp) expression. (a, b) MG132 increases P‐gp expression in a manner dependent on dose and time. HCT‐15, SW620‐14, and HT1080/3HisMDR cells...
Article Title: FBXO15 regulates P‐glycoprotein/ABCB1 expression through the ubiquitin–proteasome pathway in cancer cells
Publication Title: Cancer Science -
Description FBXO15 binds to P‐glycoprotein (P‐gp). (a) Schematic depiction of P‐gp. C‐ter, C‐terminal fragment. (b) FBXO15 is a P‐gp binding partner. HEK293 cells were transfected with a FLAG‐HA tandem‐tagged...
Article Title: FBXO15 regulates P‐glycoprotein/ABCB1 expression through the ubiquitin–proteasome pathway in cancer cells
Publication Title: Cancer Science