Asset Details
- Identifier:
- path5531-fig-0003
- Description:
- CRAMP is involved in alcohol‐induced IL‐1β production and inflammasome activation. (A) Serum concentrations of IL‐1β. (B) Serum endotoxin levels (left panel) and hepatic mRNA levels of Lbp, Cd14, and Tlr4 (right panel). (C) LPS binding activity shown as FITC intensity of FITC‐conjugated LPS‐treated RAW264.7 cells. LPS‐FITC: 1 μg/ml. Asterisks indicate the significant difference comparing LPS alone and treated groups. (D) Serum uric acid (UA) and ATP levels. Data are expressed as mean ± SEM (n = 8–10). (E) Correlation of serum levels of UA and IL‐1β in AUD patients. #Covaried with LBP. Univariate and multivariate regression model was used (n = 14–26). (F) Hepatic mRNA levels of Casp1 and Nlrp3. (G) Representative bands of immunoblotting quantification of molecules in inflammasome activation in liver lysates. Data are expressed as mean ± SEM (n = 8–10). (H) Left panel: Representative bands of immunoblotting quantification of pro‐IL‐1β and cleaved IL‐1β protein in BMDM lysates. The bands are composite images of selected bands, and the corresponding β‐actin controls are shown. Right panel: IL‐1β protein levels in culture media of BMDMs. Data are expressed as mean ± SEM (n = 4–6).
- License:
- Rights Managed
- Rights Holder:
- John Wiley & Sons, Inc.
- License Rights Holder:
- Copyright © 2020 Pathological Society of Great Britain and Ireland
- Asset Type:
- Image
- Asset Subtype:
- Figure
- Image Orientation:
- Portrait
- Image Dimensions:
- 2128 x 2559
- Image File Size:
- 1.2 MB
- Creator:
- Fengyuan Li, Cuiqing Zhao, Tuo Shao, Yunhuan Liu, Zelin Gu, Mengwei Jiang, Huimin Li, Lihua Zhang, Patrick M Gillevet, Puneet Puri, Zhong‐Bin Deng, Shao‐Yu Chen, Shirish Barve, Leila Gobejishvili, Vatsalya Vatsalya, Craig J McClain, Wenke Feng
- Credit:
- Li, F., Zhao, C., Shao, T., Liu, Y., Gu, Z., Jiang, M., Li, H., Zhang, L., Gillevet, P. M., Puri, P., Deng, Z.-B., Chen, S.-Y., Barve, S., Gobejishvili, L., Vatsalya, V., McClain, C. J., & Feng, W. (2020). Cathelicidin‐related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation. The Journal of Pathology, 252(4), 371-383..
- Collection:
- Keywords:
- Restrictions:
- Property Release:
- No
- Model Release:
- No
- Purchasable:
- Yes
- Sensitive Materials:
- No
- Article Title:
- Cathelicidin‐related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation
- Article Authors:
- Fengyuan Li, Cuiqing Zhao, Tuo Shao, Yunhuan Liu, Zelin Gu, Mengwei Jiang, Huimin Li, Lihua Zhang, Patrick M Gillevet, Puneet Puri, Zhong‐Bin Deng, Shao‐Yu Chen, Shirish Barve, Leila Gobejishvili, Vatsalya Vatsalya, Craig J McClain, Wenke Feng
- Article Copyright Year:
- 2020
- Publication Title:
- The Journal of Pathology
- Publication Volume:
- 252
- Publication Issue:
- 4
- Publication Date:
- 12/01/2020
- DOI:
Click on image to enlarge
